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Cat. No.: HY-48917

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C10 Bisphosphonate

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C10 Bisphosphonate is an acid sphingomyelinase (aSMase) inhibitor with an IC₅₀ of 0.02 μM in rats. C10 Bisphosphonate inhibits Dexamethasone (HY-14648)-induced cell apoptosis (apoptosis) and alleviates platelet-activating factor (PAF)-induced pulmonary edema. C10 Bisphosphonate can be used for the research of pulmonary edema.

For research use only. We do not sell to patients.

Purity: 98.87%
CAS No.: 15049-93-1
Formula: C₁₀H₂₅NO₆P₂
Molecular Weight:317.26

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

C10 Bisphosphonate Chemical Structure

CAS No.: 15049-93-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

All Phospholipase Isoforms :

In Vitro

C10 Bisphosphonate (compound 7c) potently inhibits aSMase derived from crude rat brain extracts, with an IC₅₀ of 0.02 μM^[1].
C10 Bisphosphonate (0.1 μM; 7 h) effectively inhibits Dexamethasone (HY-14648)-induced apoptosis of HepG2 hepatocytes^[1].
C10 Bisphosphonate (0.1-1 μM) reduces PAF-induced pulmonary edema in isolated perfused rats in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HepG2 liver cells
Concentration:

0.1 μM
Incubation Time:

7 h
Result:

Efficiently inhibited dexamethasone-induced apoptosis, as measured by reduced absorbance in a DNA-fragmentation ELISA.

Chemical Information

CAS No. 15049-93-1
Appearance Solid
Molecular Weight 317.26
Formula C₁₀H₂₅NO₆P₂
Color White to off-white
SMILES

O=P(O)(C(CCCCCCCCC)(P(O)(O)=O)N)O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Roth AG, et al. Potent and selective inhibition of acid sphingomyelinase by bisphosphonates. Angew Chem Int Ed Engl. 2009;48(41):7560-3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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C10 Bisphosphonate

All Phospholipase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

C10 Bisphosphonate Related Classifications

HY-48917 Related Classifications