2. Metabolic Enzyme/Protease Apoptosis
  3. Phospholipase Apoptosis
  4. C10 Bisphosphonate

C10 Bisphosphonate is an acid sphingomyelinase (aSMase) inhibitor with an IC50 of 0.02 μM in rats. C10 Bisphosphonate inhibits Dexamethasone (HY-14648)-induced cell apoptosis (apoptosis) and alleviates platelet-activating factor (PAF)-induced pulmonary edema. C10 Bisphosphonate can be used for the research of pulmonary edema.

For research use only. We do not sell to patients.

C10 Bisphosphonate

C10 Bisphosphonate Chemical Structure

CAS No. : 15049-93-1

Size Price Stock Quantity
1 mg In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

C10 Bisphosphonate Related Antibodies

Top Publications Citing Use of Products

View All Phospholipase Isoform Specific Products:

View All Isoforms
Phospholipase A PLD Phospholipase C

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

C10 Bisphosphonate is an acid sphingomyelinase (aSMase) inhibitor with an IC50 of 0.02 μM in rats. C10 Bisphosphonate inhibits Dexamethasone (HY-14648)-induced cell apoptosis (apoptosis) and alleviates platelet-activating factor (PAF)-induced pulmonary edema. C10 Bisphosphonate can be used for the research of pulmonary edema[1].

In Vitro

C10 Bisphosphonate (compound 7c) potently inhibits aSMase derived from crude rat brain extracts, with an IC50 of 0.02 μM[1].
C10 Bisphosphonate (0.1 μM; 7 h) effectively inhibits Dexamethasone (HY-14648)-induced apoptosis of HepG2 hepatocytes[1].
C10 Bisphosphonate (0.1-1 μM) reduces PAF-induced pulmonary edema in isolated perfused rats in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C10 Bisphosphonate Related Antibodies

Apoptosis Analysis[1]

Cell Line: HepG2 liver cells
Concentration: 0.1 μM
Incubation Time: 7 h
Result: Efficiently inhibited dexamethasone-induced apoptosis, as measured by reduced absorbance in a DNA-fragmentation ELISA.
Molecular Weight

317.26

Formula

C10H25NO6P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(C(CCCCCCCCC)(P(O)(O)=O)N)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.87%

SDS (252 KB)

COA (245 KB) RP-HPLC (1784 KB) MS (107 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

C10 Bisphosphonate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C10 Bisphosphonate15049-93-1PhospholipaseApoptosisaSMaserat brainplatelet-activating factorisolated perfused rat lungsapoptosisHepG2 liver cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
C10 Bisphosphonate
Cat. No.:
HY-48917
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.