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Thyroid+Hormone+Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Androgen Receptor (6) Apoptosis (1) Calcium Channel (1) Cytochrome P450 (3) Drug Derivative (2) Drug Metabolite (1) Endogenous Metabolite (10) Environmental Pollutants (1) Estrogen Receptor/ERR (8) FAAH (1) Histone Methyltransferase (3) Isotope-Labeled Compounds (7) mTOR (3) PI3K (3) Potassium Channel (1) Reference Standards (8) Sodium Channel (1) Thyroid Hormone Receptor (54)
By Research Areas:	Cancer (18) Cardiovascular Disease (11) Endocrinology (31) Inflammation/Immunology (6) Metabolic Disease (28) Neurological Disease (2)

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Isotope-Labeled Compounds

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GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12216

Resmetirom 20+ Cited Publications MGL-3196; VIA-3196	Thyroid Hormone Receptor	Cardiovascular Disease Endocrinology
Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC₅₀ value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis .

HY-A0070A

Liothyronine Maximum Cited Publications 39 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with K_is of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

HY-A0070

Liothyronine sodium Maximum Cited Publications 39 Publications Verification Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-14823

Sobetirome 5+ Cited Publications GC-1; QRX-431	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM .

HY-111288

MB-07811 VK-2809	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted *thyroid hormone receptor-β* agonist . MB-07811 has cholesterol and triglycerides lowering activity .

HY-141513

NH-3 4 Publications Verification	Thyroid Hormone Receptor	Neurological Disease
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC₅₀ of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment . NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0070B

Liothyronine sodium hydrate Maximum Cited Publications 39 Publications Verification Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-B1234

Octinoxate Octyl methoxycinnamate	Environmental Pollutants Estrogen Receptor/ERR Androgen Receptor Cytochrome P450 Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Octinoxate (Octyl methoxycinnamate) is a *thyroid hormone receptor* agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-W011927

4,4'-Sulfonyldiphenol Bisphenol S; Bis(4-hydroxyphenyl) sulfone	Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor Drug Derivative	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae .

HY-A0070AR

Liothyronine (Standard) 30+ Cited Publications Triiodothyronine (Standard); 3,3',5-Triiodo-L-thyronine (Standard); T3 (Standard)	Thyroid Hormone Receptor Endogenous Metabolite Reference Standards	Endocrinology Cancer
Liothyronine (Standard) is the analytical standard of Liothyronine. This product is intended for research and analytical applications. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AG

Liothyronine 1 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor	Endocrinology Cancer
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-126996

Triiodothyronine sulfate	Drug Metabolite Endogenous Metabolite	Metabolic Disease
Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to *β1 thyroid hormone receptor* (TRβ1)**, and activates its activity .

HY-10473

Eprotirome KB2115	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Eprotirome (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. KB2115 has modestly higher affinity for TRβ than for TRα. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research .

HY-168046

ALG-055009	Thyroid Hormone Receptor	Metabolic Disease
ALG-055009 is a selective and orally active Thyroid Hormone Receptor Beta (THR-β) agonist with an EC₅₀ of 0.063 μM. ALG-055009 binds to the T3 hormone pocket of human THR-β, forming polar interactions with protein residues. ALG-055009 can lower total cholesterol levels in rats on a high-fat diet. ALG-055009 exhibits high metabolic stability, good permeability, a long in vivo half-life, and limited drug-drug interaction liability. ALG-055009 can be used in studies related to metabolic dysfunction-associated fatty liver disease .

HY-127024

Thyroid hormone receptor antagonist (1-850)	Thyroid Hormone Receptor	Metabolic Disease
Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC₅₀ of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. Thyroid hormone receptor antagonist (1-850) has no effect on the activity of RARα .

HY-130012

CO23 1 Publications Verification	Thyroid Hormone Receptor	Metabolic Disease
CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation .

HY-111443

TR antagonist 1 4 Publications Verification	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC₅₀s of 36 and 22 nM for TRα and TRβ, respectively.

HY-N0791

Tectoridin 1 Publications Verification	Estrogen Receptor/ERR	Cancer
Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway .

HY-126236

3,5-Diiodothyropropionic acid 1 Publications Verification	Thyroid Hormone Receptor	Cardiovascular Disease Endocrinology
3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to *thyroid hormone receptor* (TR), with K_a of 2.40 and 4.06 M ^-1 for TRα1 and TRβ1, respectively. 3,5-Diiodothyropropionic acid promotes angiogenesis in 3-D human dermal microvascular endothelial cell sprouting assay. 3,5-Diiodothyropropionic acid prevents myocardial arteriolar loss in thyroidectomized rats and enhances cardiac energy-generating capacity in postinfarction heart failure rats. 3,5-Diiodothyropropionic can be used in studies related to angiogenesis and heart failure .

HY-W011927S

4,4'-Sulfonyldiphenol-d8 1 Publications Verification Bisphenol S (4,4'-Sulfonyldiphenol)-d₈	Isotope-Labeled Compounds Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
4,4'-Sulfonyldiphenol-d₈ (Bisphenol S (4,4'-Sulfonyldiphenol)-d₈) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

HY-12753A

Debutyldronedarone hydrochloride 2 Publications Verification SR35021 hydrochloride	Thyroid Hormone Receptor	Cardiovascular Disease
Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁ by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .

HY-120026

KB130015 1 Publications Verification KB015	Thyroid Hormone Receptor Calcium Channel Potassium Channel Sodium Channel	Cardiovascular Disease
KB130015 (KB015) is an orally active and potent ThRα and ThRβ (thyroid hormone receptor) inhibitor, with IC₅₀ values of 4.5 and 5.1 μM, respectively. KB130015 markedly slows the kinetics of inactivation of Na ⁺ channels. KB130015 activates hERG1 channels (EC₅₀ = 12.2 μM) and large-conductance Ca ²⁺-activated K ⁺ (BKCa) channels formed by hSlo1 (α) subunits in HEK 293 cells. KB130015 has antiarrhythmic properties. KB130015 can be used for the study of cardiovascular disease .

HY-19513

MB-07344	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a K_i of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .

HY-146997

TRβ agonist 1	Thyroid Hormone Receptor	Metabolic Disease
TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC₅₀ value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH) .

HY-A0070R

Liothyronine sodium (Standard) Triiodothyronine sodium (Standard); 3,3',5-Triiodo-L-thyronine sodium (Standard); T3 sodium (Standard)	Reference Standards Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-163945

ZTA-261	Thyroid Hormone Receptor	Metabolic Disease
ZTA-261 is a highly selective and low toxic thyroid hormone receptor β subtype (THR-β) agonist (IC₅₀=6.3 nM) that reduces body weight and visceral fat through a liothyronine (HY-A0070A) mediated pathway. ZTA-261 can be used in the study of lipid metabolism and obesity prevalence .

HY-Q04764

TI17	Thyroid Hormone Receptor Apoptosis	Cancer
TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage .

HY-127024A

TR antagonist 2	Thyroid Hormone Receptor	Metabolic Disease
TR antagonist 2 (Compound 10a) is a competitive thyroid hormone receptors (TRα/β) antagonist (IC₅₀=47 nM). TR antagonist 2 competes with triiodothyronine (T₃) for binding to the ligand-binding domain of TR to block receptor-coactivator complex formation and inhibit target gene transcription, reducing thyroid hormone-mediated hypermetabolic effects. TR antagonist 2 is promising for research of hyperthyroidism (e.g., Graves' disease) and thyrotoxicosis .

HY-164495

Sob-AM2	FAAH Thyroid Hormone Receptor	Inflammation/Immunology Endocrinology
Sob-AM2 is a potent substrate (K_m=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice .

HY-A0070AS1

Liothyronine-13C9,15N Triiodothyronine-¹³C₉,¹⁵N; 3,3',5-Triiodo-L-thyronine-¹³C₉,¹⁵N; T3-¹³C₉,¹⁵N	Thyroid Hormone Receptor Endogenous Metabolite	Cancer
Liothyronine- ¹³C₉, ¹⁵N is the ¹³C and ¹⁵N labeled Liothyronine . Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-14823G

Sobetirome GC-1; QRX-431	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Sobetirome (GMP) is Sobetirome (HY-14823) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM .

HY-W011927R

4,4'-Sulfonyldiphenol (Standard) Bisphenol S (Standard); Bis(4-hydroxyphenyl) sulfone (Standard)	Reference Standards Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor Drug Derivative	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

HY-A0070C

Liothyronine hydrochloride Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-19513A

MB-07344 sodium	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a K_i of 2.17 nM. MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .

HY-A0070AS2

Liothyronine-13C6-1 Triiodothyronine-¹³C₆-1; 3,3',5-Triiodo-L-thyronine-¹³C₆-1; T3-¹³C₆-1	Thyroid Hormone Receptor	Endocrinology Cancer
Liothyronine- ¹³C₆-1 is a ¹³C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AS3

Liothyronine-d3 Triiodothyronine-d₃; 3,3',5-Triiodo-L-thyronine-d₃; T3-d₃	Endogenous Metabolite Thyroid Hormone Receptor Isotope-Labeled Compounds	Endocrinology Cancer
Liothyronine-d₃ is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-178015

THR-β agonist 11	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases .

HY-153477

Thyroid hormone receptor beta agonist-1	Thyroid Hormone Receptor	Cancer
Thyroid hormone receptor beta agonist-1 (compound 3) is a thyroid beta-agonist .

HY-111442

GC 14	Thyroid Hormone Receptor	Metabolic Disease
GC 14 is a selective *thyroid hormone receptor* antagonist, with IC₅₀ values of 35 nM and 200 nM for hTRβ and hTRα, respectively.

HY-142441

THR-β agonist 1	Thyroid Hormone Receptor	Endocrinology
THR-β Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THR-β Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2) .

HY-149218

THR-β agonist 6	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC₅₀s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research .

HY-A0070AS5

Liothyronine-d4 Triiodothyronine-d₄; 3,3',5-Triiodo-L-thyronine-d₄; T3-d₄	Isotope-Labeled Compounds Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine-d₄ (Triiodothyronine-d₄) is the deuterium labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with vs of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

HY-153637

THR-β modulator-1	Thyroid Hormone Receptor	Endocrinology
THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor β modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders .

HY-160416

THR-β modulator-2	Thyroid Hormone Receptor	Endocrinology
THR-β modulator-2 (compound 40) is a thyroid hormone receptor β (THR-β) modulator .

HY-125787

MLS000389544	Thyroid Hormone Receptor	Metabolic Disease
MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2) .

HY-14823R

Sobetirome (Standard) GC-1 (Standard); QRX-431 (Standard)	Thyroid Hormone Receptor Reference Standards	Metabolic Disease Endocrinology
Sobetirome (Standard) is the analytical standard of Sobetirome. This product is intended for research and analytical applications. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM .

HY-143613A

THR-β agonist 2 diacetate	Thyroid Hormone Receptor	Metabolic Disease
THR-β agonist 2 (Compound 3) diacetate is a selective thyroid hormone receptor β (THRβ) agonist with an EC₅₀ of 1.42 μM. THR-β agonist 2 diacetate can regulate the biological pathways mediated by thyroid hormones. THR-β agonist 2 diacetate can be used for the study of metabolic diseases .

HY-N0791R

Tectoridin (Standard)	Reference Standards Estrogen Receptor/ERR	Cancer
Tectoridin (Standard) is the analytical standard of Tectoridin. This product is intended for research and analytical applications. Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway .

HY-12753AS

Debutyldronedarone-d7 hydrochloride SR35021-d7 hydrochloride	Thyroid Hormone Receptor Isotope-Labeled Compounds	Cardiovascular Disease
Debutyldronedarone-d₇ hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁ by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .

HY-12753AR

Debutyldronedarone hydrochloride (Standard) SR35021 hydrochloride (Standard)	Reference Standards Thyroid Hormone Receptor	Cardiovascular Disease
Debutyldronedarone (hydrochloride) (Standard) is the analytical standard of Debutyldronedarone (hydrochloride). This product is intended for research and analytical applications. Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁ by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .

Cat. No.	Product Name

HY-L047

Endocrinology Compound Library

881 compounds

The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function.

The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease.

MCE offers a unique collection of 881 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Cat. No.	Product Name	Type

HY-A0070AG

Liothyronine 1 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Fluorescent Dyes
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-14823G

Sobetirome GC-1; QRX-431	Fluorescent Dyes
Sobetirome (GMP) is Sobetirome (HY-14823) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM .

Cat. No.	Product Name	Type

HY-W011927

4,4'-Sulfonyldiphenol

Bisphenol S; Bis(4-hydroxyphenyl) sulfone

Biochemical Assay Reagents

4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae .

HY-A0070AG

Liothyronine 1 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Biochemical Assay Reagents
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-14823G

Sobetirome GC-1; QRX-431	Biochemical Assay Reagents
Sobetirome (GMP) is Sobetirome (HY-14823) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM .

HY-W011927R

4,4'-Sulfonyldiphenol (Standard)

Bisphenol S (Standard); Bis(4-hydroxyphenyl) sulfone (Standard)

Biochemical Assay Reagents

4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0070A

Liothyronine Maximum Cited Publications 39 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with K_is of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

HY-A0070

Liothyronine sodium Maximum Cited Publications 39 Publications Verification Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium	Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070B

Liothyronine sodium hydrate Maximum Cited Publications 39 Publications Verification Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate	Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-B1234

Octinoxate Octyl methoxycinnamate	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Cosmetic Research Plants Disease Research Fields Source Classification	Environmental Pollutants Estrogen Receptor/ERR Androgen Receptor Cytochrome P450 Thyroid Hormone Receptor
Octinoxate (Octyl methoxycinnamate) is a *thyroid hormone receptor* agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-A0070AR

Liothyronine (Standard) 30+ Cited Publications Triiodothyronine (Standard); 3,3',5-Triiodo-L-thyronine (Standard); T3 (Standard)	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Thyroid Hormone Receptor Endogenous Metabolite Reference Standards
Liothyronine (Standard) is the analytical standard of Liothyronine. This product is intended for research and analytical applications. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-126996

Triiodothyronine sulfate	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to *β1 thyroid hormone receptor* (TRβ1)**, and activates its activity .

HY-N0791

Tectoridin 1 Publications Verification	Flavonoids Flavones Leguminosae Maackia amurensis Rupr. et Maxim. Plants	Estrogen Receptor/ERR
Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway .

HY-A0070R

Liothyronine sodium (Standard) Triiodothyronine sodium (Standard); 3,3',5-Triiodo-L-thyronine sodium (Standard); T3 sodium (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Reference Standards Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070C

Liothyronine hydrochloride Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride	Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-N0791R

Tectoridin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Maackia amurensis Rupr. et Maxim. Plants	Reference Standards Estrogen Receptor/ERR
Tectoridin (Standard) is the analytical standard of Tectoridin. This product is intended for research and analytical applications. Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway .

Recombinant Proteins Recommended:

Thyroid Hormone Receptor

Species:	Human (5)
Tag:	His (3) Strep (1) Tag Free (2) GST (1) Flag (1)
Source:	Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703649

	THRA Protein, Human (His) Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7 (EAR-7); c-erbA-1; c-erbA-alpha; EAR7; ERBA1; NR1A1; THRA1; THRA2	Human	E. coli
	THRA Protein, Human (His) is the recombinant human-derived THRA protein, expressed by E. coli, with N-6*His tag.

HY-P701866

	TRIP13 Protein, Human TRIP13; Pachytene checkpoint protein 2 homolog; Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13	Human	E. coli
	The TRIP13 protein plays a key role in meiosis, affecting chromosome reorganization and structural development. It is critical for the formation of crossing and noncrossing pathways, homologous synapses, and synaptonemal complexes. TRIP13 Protein, Human is the recombinant human-derived TRIP13 protein, expressed by E. coli , with tag free.

HY-P701865

	TRIP13 Protein, Human (His, StrepⅡ) TRIP13; Pachytene checkpoint protein 2 homolog; Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13	Human	E. coli
	The TRIP13 protein plays a key role in meiosis, affecting chromosome reorganization and structural development. It is critical for the formation of crossing and noncrossing pathways, homologous synapses, and synaptonemal complexes. TRIP13 Protein, Human (His, Strep) is the recombinant human-derived TRIP13 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

HY-P701373

	CDK8-CCNC-MED12 Complex Protein, Human (Active, sf9, GST, FLAG, His) 1 Publications Verification CDK8; CCNC; MED12; Cyclin-dependent kinase 8; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein	Human	Sf9 insect cells
	The CDK8-CCNC-MED12 protein is an important component of the mediator complex, acting as a bridge for gene transcription regulation, transmitting information from gene-specific regulatory factors to RNA polymerase II. It is recruited to the promoter, assembles a preinitiation complex, and promotes transcription. CDK8-CCNC-MED12 Protein, Human (sf9, GST, FLAG, His) is the recombinant human-derived CDK8-CCNC-MED12 protein, expressed by sf9 insect cells , with N-6*His, N-Flag, N-GST labeled tag.

HY-P701363

	CDK19-CCNC-MED12 Protein, Human (sf9) CDK19; CCNC; MED12; Cyclin-dependent kinase 19; CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein	Human	Sf9 insect cells
	CDK19 plays a key role in cellular homeostasis and developmental programming. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells. Besides, CDK19 is the paralog of CDK8. CDK8 and CDK19 can cooperate with each other in stimulating NFκB-induced transcription and Dengue virus replication. CDK19-CCNC-MED12 Protein, Human (sf9) is the recombinant human-derived CDK19-CCNC-MED12 protein, expressed by sf9 insect cells , with tag free. ,

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Cat. No.	Product Name	Chemical Structure

HY-W011927S

4,4'-Sulfonyldiphenol-d8

1 Publications Verification

4,4'-Sulfonyldiphenol-d₈ (Bisphenol S (4,4'-Sulfonyldiphenol)-d₈) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

HY-A0070AS1

Liothyronine-13C9,15N
Liothyronine- ¹³C₉, ¹⁵N is the ¹³C and ¹⁵N labeled Liothyronine . Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AS2

Liothyronine-13C6-1
Liothyronine- ¹³C₆-1 is a ¹³C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AS3

Liothyronine-d3
Liothyronine-d₃ is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AS5

Liothyronine-d4
Liothyronine-d₄ (Triiodothyronine-d₄) is the deuterium labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with vs of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

HY-12753AS

Debutyldronedarone-d7 hydrochloride

Debutyldronedarone-d₇ hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁ by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .

HY-B1234S

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-W713284

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate

2-Ethylhexyl (E)-3-(4-(methoxy-d₃)phenyl)acrylate is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-12216S

Resmetirom-13C3,15N
Resmetirom- ¹³C₃, ¹⁵N (MGL-3196- ¹³C₃, ¹⁵N) is the ¹³C- and ¹⁵N-labeled Resmetirom (HY-12216). Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC₅₀ value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis .

Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Rat (1)
Application:	IHC-P (3) ICC/IF (3) IHC-F (2) WB (5) FC (2) ELISA (1)
Isotype:	IgG (4) IgG1 (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (3)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87448

	Thyroid Hormone Receptor beta/THRB Antibody (YA7135)	WB, IHC-P, IHC-F, ICC/IF, FC	Human
	Thyroid Hormone Receptor beta/THRB Antibody (YA7135) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Thyroid Hormone Receptor beta/THRB.

HY-P87448A

	Thyroid Hormone Receptor beta/THRB Antibody (YA7135)(PBS only) ERBA2, NR1A2, THR1, THRB, Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta	WB, IHC-P, IHC-F, ICC/IF, FC	Human
	Thyroid Hormone Receptor beta/THRB Antibody (YA7135) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Thyroid Hormone Receptor beta/THRB.

HY-P82828

	Thyroid Hormone Receptor alpha Antibody (YA2573) AR7; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA; THRA1; THRA2	WB	Human
	Thyroid Hormone Receptor alpha Antibody (YA2573) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thyroid Hormone Receptor alpha.

HY-P86772

	ASC1 Antibody (YA6465) Activating signal cointegrator 1 antibody; ASC 1 antibody; ASC-1 antibody; HsT17391 antibody; Thyroid hormone receptor interactor 4 antibody; Thyroid receptor interacting protein 4 antibody; Thyroid receptor-interacting protein 4 antibody; TR-interacting protein 4 antibody; TR; IP : 4 antibody; TRIP-4 antibody; Activating signal cointegrator 1 antibody; ASC 1 antibody; ASC-1 antibody; HsT17391 antibody; Thyroid hormone receptor interactor 4 antibody; Thyroid receptor interacting protein 4 antibody; Thyroid receptor-interacting protein 4 antibody; TR-interacting protein 4 antibody; TR; IP : 4 antibody; TRIP-4 antibody; Trip4 antibody; TRIP4_HUMAN antibody; ZC2HC5 antibody; Zinc finger C2HC5 type antibody;	WB, IHC-P	Human, Rat
	ASC1 Antibody (YA6465) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ASC1.

HY-P85872

	MED1 Antibody (YA5564) Mediator of RNA polymerase II transcription subunit 1; Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Peroxisome proliferator-activated receptor-binding protein; PBP; PPAR-binding protein; Thyroid hormone receptor-associated protein complex 220 kDa component; Trap220; Thyroid receptor-interacting protein 2; TR-interacting protein 2; TRIP-2; Vitamin D receptor-interacting protein complex component DRIP205;	WB, ICC/IF, ELISA	Human
	MED1 Antibody (YA5564) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MED1.

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0070AG

Liothyronine 1 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor	Endocrinology Cancer
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-14823G

Sobetirome GC-1; QRX-431	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Sobetirome (GMP) is Sobetirome (HY-14823) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM .

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Thyroid+Hormone+Receptor

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