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Tectoridin 

Cat. No.: HY-N0791
Handling Instructions

Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway.

For research use only. We do not sell to patients.

Tectoridin Chemical Structure

Tectoridin Chemical Structure

CAS No. : 611-40-5

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Description

Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2].

In Vitro

Tectoridin scarcely binds to ER alpha as compared to 17beta-estradiol and genistein[2].
Tectoridin induceds potent estrogenic effects, namely recovery of the population of cells in the S-phase after serum starvation, transactivation of the estrogen response element, and induction of MCF-7 cell proliferation[2].
Tectoridin induces estrogenic effect, and this effect is severely abrogated by treatment with U0126 ( MEK1/2 inhibitor). Tectoridin promotes phosphorylation of ERK1/2, but does not affect phosphorylation of ER alpha at Ser (118). It also increases cellular accumulation of cAMP[2].

Molecular Weight

462.40

Formula

C₂₂H₂₂O₁₁

CAS No.

611-40-5

SMILES

O=C(C(C1=CC=C(O)C=C1)=COC2=CC(O[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]3O)O)O[[email protected]@H]3CO)=C4OC)C2=C4O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TectoridinEstrogen Receptor/ERRInhibitorinhibitorinhibit

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Tectoridin
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