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  2. Thyroid Hormone Receptor
  3. 3,5-Diiodothyropropionic acid

3,5-Diiodothyropropionic acid 

Cat. No.: HY-126236 Purity: 98.94%
Handling Instructions

3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively.

For research use only. We do not sell to patients.

3,5-Diiodothyropropionic acid Chemical Structure

3,5-Diiodothyropropionic acid Chemical Structure

CAS No. : 1158-10-7

Size Price Stock Quantity
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively[1].

Molecular Weight

510.06

Formula

C₁₅H₁₂I₂O₄

CAS No.

1158-10-7

SMILES

O=C(O)CCC1=CC(I)=C(OC2=CC=C(O)C=C2)C(I)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (98.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9606 mL 9.8028 mL 19.6055 mL
5 mM 0.3921 mL 1.9606 mL 3.9211 mL
10 mM 0.1961 mL 0.9803 mL 1.9606 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
3,5-Diiodothyropropionic acid
Cat. No.:
HY-126236
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