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GC 14 

Cat. No.: HY-111442
Handling Instructions

GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.

For research use only. We do not sell to patients.

GC 14 Chemical Structure

GC 14 Chemical Structure

CAS No. : 447415-34-1

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Description

GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.

IC50 & Target

IC50: 35 nM (hTRβ), 200 nM (hTRα)[1][2].

In Vitro

GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions[3].

Molecular Weight

449.50

Formula

C₂₆H₂₇NO₆

CAS No.

447415-34-1

SMILES

O=C(O)COC1=CC(C)=C(CC2=CC(C3=CC=C([N+]([O-])=O)C=C3)=C(O)C(C(C)C)=C2)C(C)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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GC 14
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HY-111442
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