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Results for "

cyclic adenosine monophosphate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (6) Cyclic GMP-AMP Synthase (1) 5-HT Receptor (1) Adenylate Cyclase (4) Adrenergic Receptor (7) Amino Acid Derivatives (1) Antibiotic (3) Apoptosis (8) Bacterial (7) Bcl-2 Family (1) Biochemical Assay Reagents (1) Calcium Channel (11) Calmodulin (1) CGRP Receptor (1) CRFR (1) CXCR (1) Cytochrome P450 (1) Dopamine Receptor (6) Endogenous Metabolite (3) Environmental Pollutants (1) Estrogen Receptor/ERR (1) GLP Receptor (1) GPR119 (1) Guanylate Cyclase (1) IFNAR (1) Isotope-Labeled Compounds (5) mAChR (5) MMP (2) Monoamine Oxidase (2) NF-κB (2) NO Synthase (1) Nucleoside Antimetabolite/Analog (2) Opioid Receptor (1) Parasite (1) Phosphodiesterase (PDE) (27) PKA (10) Potassium Channel (4) Ras (1) Reactive Oxygen Species (ROS) (6) Reference Standards (8) STING (2) Vasopressin Receptor (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (23) Endocrinology (3) Infection (9) Inflammation/Immunology (19) Metabolic Disease (8) Neurological Disease (30)
Oligonucleotides:	Nucleotide Analogs (2) Adenine Nucleotide (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Targets Recommended: Adenosine Kinase Adenosine Deaminase Adenosine Receptor IMPDH HCN Channel Cyclic GMP-AMP Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0764

Bucladesine sodium Maximum Cited Publications 41 Publications Verification Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-B1511

Cyclic AMP Maximum Cited Publications 25 Publications Verification cyclic adenosine monophosphate; adenosine cyclic 3', 5'-monophosphate; cAMP	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

HY-B1511A

Cyclic AMP sodium 20+ Cited Publications cyclic adenosine monophosphate sodium; adenosine cyclic 3', 5'-monophosphate sodium; cAMP sodium	Biochemical Assay Reagents	Neurological Disease Metabolic Disease Cancer
Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes .

HY-131454

SR-717 25+ Cited Publications	STING	Inflammation/Immunology Cancer
SR-717 is a non-nucleotide STING agonist with EC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .

HY-119708

Ensifentrine 1 Publications Verification RPL-554	Phosphodiesterase (PDE)	Infection Neurological Disease Inflammation/Immunology Cancer
Ensifentrine (RPL-554) is an inhaled dual inhibitor of PDE3 and PDE4 with IC₅₀s of 0.4 nM and 1479 nM, respectively. Ensifentrine blocks PDE3 and PDE4 enzymes, thereby increasing the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, dilating the bronchi, and inhibiting the activation and migration of inflammatory cells. Ensifentrine can be used in the research of chronic obstructive pulmonary disease (COPD) .

HY-B0764A

Bucladesine hemicalcium Maximum Cited Publications 41 Publications Verification Dibutyryl cAMP hemicalcium; DBcAMP hemicalcium	PKA Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) hemicalcium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-103192

MDL12330A 5 Publications Verification RMI12330A	Adenylate Cyclase Potassium Channel	Neurological Disease Cancer
MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit K_V channels, increases insulin secretion and Ca ²⁺ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .

HY-N0113

Hordenine 1 Publications Verification Ordenina; Peyocactine	Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-B1294

Amrinone Inamrinone	Phosphodiesterase (PDE)	Cardiovascular Disease
Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .

HY-B0549A

Flavoxate hydrochloride Rec-7-0040; DW61	Calcium Channel Adenosine Receptor mAChR Dopamine Receptor Adrenergic Receptor	Cardiovascular Disease Infection Neurological Disease Cancer
Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

HY-B1511S

Cyclic AMP-13C5 cyclic adenosine monophosphate-¹³C₅; adenosine cyclic 3', 5'-monophosphate-¹³C₅; cAMP-¹³C₅	Isotope-Labeled Compounds	Others
Cyclic AMP- ¹³C₅ is a deuterated cyclic AMP.

HY-N0126

Xanthone 3 Publications Verification	Environmental Pollutants Calcium Channel Monoamine Oxidase	Cardiovascular Disease Neurological Disease
Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds .

HY-B1209

Etofylline 7-(β-Hydroxyethyl)theophylline	Phosphodiesterase (PDE)	Cardiovascular Disease Inflammation/Immunology
Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos .

HY-W587488

Adenosine 3′-monophosphate 3′-AMP	Nucleoside Antimetabolite/Analog Cyclic GMP-AMP Synthase	Cancer
Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A_2B receptors .

HY-108974

Drotaverine hydrochloride	Phosphodiesterase (PDE) Calcium Channel	Neurological Disease
Drotaverine hydrochloride is a type *4 cyclic* nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC)** blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.

HY-131454A

SR-717 free acid 25+ Cited Publications	STING	Inflammation/Immunology Cancer
SR-717 free acid is a non-nucleotide STING agonist with EC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .

HY-103322

6-Bnz-cAMP sodium salt	PKA Potassium Channel	Metabolic Disease Cancer
6-Bnz-cAMP sodium, a derivative of cyclic adenosine monophosphate (cAMP), is a selective PKA activator with inhibitory activity against the bTREK-1 K ⁺ channel. 6-Bnz-cAMP sodium does not activate the Epac signaling pathway. It inhibits the bTREK-1 K ⁺ channel via a voltage-independent, ATP-dependent mechanism that is independent of the PKA/Epac/calmodulin kinase/MAP kinase pathway. 6-Bnz-cAMP sodium activates CREB phosphorylation to regulate osteoblast-specific gene expression, induces osteoblast differentiation, promotes extracellular matrix mineralization, supports osteoblast proliferation, and shows no cytotoxicity toward osteoblasts. It can be used in studies related to bone tissue repair and regeneration .

HY-B1511R

Cyclic AMP (Standard) cyclic adenosine monophosphate (Standard); adenosine cyclic 3', 5'-monophosphate (Standard); cAMP (Standard)	Endogenous Metabolite Reference Standards	Cancer
Cyclic AMP (Standard) is the analytical standard of Cyclic AMP. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

HY-120511

KNT-127 1 Publications Verification	Opioid Receptor	Neurological Disease
KNT-127 is a selective and BBB-penetrant δ-opioid receptor (DOR) agonist (K_i = 0.16 nM). KNT-127 is highly selective to the δ receptor, with Ki values of 0.16, 21.3 and 153 nM for δ, μ and κ receptors, respectively. KNT-127 acts as a biased ligand that mainly activates cyclic adenosine monophosphate (cAMP) signaling with lower beta-arrestin signaling activation. KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens, and prefrontal cortex. KNT-127 exhibits antidepressant- and anxiolytic-like effects. KNT-127 can be studied in research on neurological diseases .

HY-B0764B

Bucladesine Dibutyryl cAMP; DBcAMP	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-173178

LNS8801	Estrogen Receptor/ERR	Cancer
LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting the production of cyclic adenosine monophosphate (cAMP) and activating the cAMP response element-binding protein (CREB) signaling, thereby exerting anti-tumor activities including inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. LNS8801 can be used in the research of various cancers (e.g., melanoma, pancreatic cancer, colorectal cancer, lung cancer, etc.) and relevant studies exploring the roles of GPER in normal physiological and pathological processes .

HY-146356

Adenylyl cyclase type 2 agonist-1	Adenylate Cyclase	Inflammation/Immunology
Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC₅₀ of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases .

HY-B0764G

Bucladesine sodium Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (GMP) is a Bucladesine sodium (HY-B0764) produced by using GMP guidelines. Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-12463A

Carmoterol	Adrenergic Receptor	Inflammation/Immunology
Carmoterol is a highly potent and selective long-acting β2-adrenergic receptor agonist with a pEC₅₀ of 10.19. Carmoterol shows 53-fold higher affinity for β2-adrenergic receptors than for β1-adrenergic receptors. Carmoterol stimulates cyclic adenosine monophosphate accumulation, induces airway smooth muscle relaxation, inhibits bronchoconstriction, reduces thromboxane B₂ release, and prolongs survival time. Carmoterol can be used in research related to asthma and chronic obstructive pulmonary disease (COPD) .

HY-134375

cAIMP cyclic adenosine-Inosine monophosphate	NF-κB IFNAR	Inflammation/Immunology
cAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual). cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC₅₀ of 6.4 μmol/L .

HY-N0113B

Hordenine hydrochloride 1 Publications Verification Ordenina hydrochloride; Peyocactine hydrochloride	Bacterial	Infection
Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-P2867

Phosphodiesterase II, Bovine Spleen 3′-Exonuclease	Phosphodiesterase (PDE)	Neurological Disease
Phosphodiesterase II (EC 3.1.16.1), namely phosphodiesterase 2, is mainly involved in the hydrolysis of the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), and is often used in biochemical research. Phosphodiesterase II is expressed in a variety of tissues, such as the adrenal medulla, brain, heart, platelets, macrophages and endothelial cells, and is involved in the regulation of many different intracellular processes .

HY-N0113S

Hordenine-d6 Ordenina-d₆; Peyocactine-d₆	Isotope-Labeled Compounds Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-B0764R

Bucladesine sodium (Standard) Dibutyryl cAMP sodium (Standard); DBcAMP sodium (Standard)	Reference Standards PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (Standard) is the analytical standard of Bucladesine sodiumn (HY-B0764). This product is intended for research and analytical applications. Bucladesine is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-114727

PDE7-IN-4	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases .

HY-P4520

(Trp4)-Kemptide	Amino Acid Derivatives	Others
(Trp4)-Kemptide is a peptide substrate for adenosine 3',5'-cyclic monophosphate-dependent protein kinase .

HY-159857

Gp(2′-5′)Ap sodium Gp(2′-5′)Ap(3′) sodium; 2'5'-GpAp sodium; Guanylyl-(2′→5′)-3′-adenylic acid sodium	Nucleoside Antimetabolite/Analog
Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.

HY-B0549

Flavoxate Rec-7-0040 free base; DW61 free base	mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor	Neurological Disease
Flavoxate (Rec-7-0040 free base; DW61 free base) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate can be used in research on overactive bladder and related voiding dysfunctions .

HY-B0549AR

Flavoxate hydrochloride (Standard) Rec-7-0040 (Standard); DW61 (Standard)	Reference Standards mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor	Neurological Disease
Flavoxate (hydrochloride) (Standard) is the analytical standard of Flavoxate (hydrochloride). This product is intended for research and analytical applications. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

HY-P2781

3′,5′-Cyclic nucleotide phosphodiesterase	Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
3′,5′-Cyclic nucleotide phosphodiesterase is a hydrolytic enzyme that degrades **cyclic 3', 5' -adenosine monophosphate** (cyclic AMP). 3′,5′-Cyclic nucleotide phosphodiesterase is promising for research of cardiovascular diseases, inflammation, central nervous system disorders, and metabolic syndrome .

HY-115269

CK-2289	Phosphodiesterase (PDE)	Cardiovascular Disease
CK-2289 is an inhibitor of type III cyclic 3'5'-adenosine monophosphate phosphodiesterase (PDE). CK-2289 can inhibit platelet aggregation and decreases mean arterial blood pressure. CK-2289 can be used for the research of cardiovascular disease, such as congestive heart failure .

HY-174986

CGRP antagonist 7	CGRP Receptor	Cardiovascular Disease
CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a K_i of 0.029 nM. CGRP antagonist 7 Inhibit the production of cyclic adenosine monophosphate (cAMP) with an IC₅₀ of 1.5 nM. CGRP antagonist 7 can be used for the study of migraine .

HY-130629

VHC-7	Adenylate Cyclase	Neurological Disease
VHC-7 is a potent and selective adenylyl cyclase type 8 (AC8) agonist, with an EC₅₀ value of 105.2 nM. VHC-7 increases cyclic adenosine monophosphate (cAMP) levels. VHC-7 can be used for the study of central nervous system disorders and heart diseases .

HY-134263

8-Br-cAMP-AM	PKA Ras	Cardiovascular Disease
8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury .

HY-N0126R

Xanthone (Standard) 3 Publications Verification	Reference Standards Monoamine Oxidase Calcium Channel	Cardiovascular Disease Neurological Disease
Xanthone (Standard) is the analytical standard of Xanthone (HY-N0126). This product is intended for research and analytical applications. Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds .

HY-168481

GLP-1R agonist 27	GLP Receptor	Metabolic Disease
GLP-1R agonist 27 (compound 21) is a potent and orally active GLP-1R agonist. GLP-1R agonist 27 promots cyclic adenosine monophosphate (cAMP) accumulation. GLP-1R agonist 27 reduces blood glucose levels and food intake. GLP-1R agonist 27 has the potential for the research of obesity and type 2 diabetes mellitus (T2DM) .

HY-14132

BMS-665053	CRFR	Neurological Disease
BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC₅₀ = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC₅₀ = 4.9 nM) .

HY-B1511G

Cyclic AMP cyclic adenosine monophosphate; adenosine cyclic 3', 5'-monophosphate; cAMP	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Cyclic AMP (GMP) (Cyclic adenosine monophosphate (GMP)) is Cyclic AMP (HY-B1511) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

HY-134283

8-Benzylthio-cAMP	PKA Apoptosis	Others
8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP). 8-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinases. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis .

HY-116850

Oxagrelate EG626; Phthalazinol; SC-32840	Phosphodiesterase (PDE)	Neurological Disease
Oxagrelate is a specific inhibitor of cyclic adenosine monophosphate phosphodiesterase and exhibits concentration-dependent inhibition of collagen- and ADP-induced platelet aggregation in vitro .

HY-N14662

Griseolic acid B 7′-Desoxygriseolic acid	Phosphodiesterase (PDE)	Neurological Disease
Griseolic acid B (7′-Desoxygriseolic acid) has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with an IC₅₀ of 0.16 μM .

HY-129210

KMUP-4	Phosphodiesterase (PDE) Potassium Channel	Cardiovascular Disease
KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K ⁺ channels. KMUP-4 can be used in the study of cardiovascular diseases .

HY-N0113R

Hordenine (Standard) Ordenina (Standard); Peyocactine (Standard)	Reference Standards Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine (Standard) is the analytical standard of Hordenine. This product is intended for research and analytical applications. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-131823

5,6-DCl-cBIMP	Phosphodiesterase (PDE)	Others
5,6-DCl-cBIMP, a cyclic adenosine monophosphate analog, can act as an agonist of PDE2 and significantly enhance the cAMP and cGMP hydrolytic activities of PDE2 .

HY-N0113BR

Hordenine hydrochloride (Standard) Ordenina hydrochloride (Standard); Peyocactine hydrochloride (Standard)	Reference Standards Bacterial	Infection
Hordenine (hydrochloride) (Standard) is the analytical standard of Hordenine (hydrochloride). This product is intended for research and analytical applications. Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production[1].

Cat. No.	Product Name	Type

HY-B1511G

Cyclic AMP

cyclic adenosine monophosphate; adenosine cyclic 3', 5'-monophosphate; cAMP

Fluorescent Dyes

Cyclic AMP (GMP) (Cyclic adenosine monophosphate (GMP)) is Cyclic AMP (HY-B1511) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

Cat. No.	Product Name	Type

HY-B1511A

Cyclic AMP sodium 20+ Cited Publications cyclic adenosine monophosphate sodium; adenosine cyclic 3', 5'-monophosphate sodium; cAMP sodium	Biochemical Assay Reagents
Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes .

HY-B1511G

Cyclic AMP

cyclic adenosine monophosphate; adenosine cyclic 3', 5'-monophosphate; cAMP

Biochemical Assay Reagents

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1511

Cyclic AMP Maximum Cited Publications 25 Publications Verification cyclic adenosine monophosphate; adenosine cyclic 3', 5'-monophosphate; cAMP	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

HY-N0113

Hordenine 1 Publications Verification Ordenina; Peyocactine	Cardiovascular Disease Alkaloids Monophenols other families Classification of Application Fields Other Alkaloids Phenols Plants Disease Research Fields Source Classification	Bacterial Antibiotic
Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0126

Xanthone 3 Publications Verification	Infection Structural Classification Xanthones Classification of Application Fields Guttiferae Phenols Garcinia mangostana Linn. Plants Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Calcium Channel Monoamine Oxidase
Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds .

HY-N0113B

Hordenine hydrochloride 1 Publications Verification Ordenina hydrochloride; Peyocactine hydrochloride	Coryphantha vivipara var arizonica Structural Classification Alkaloids Monophenols Cactaceae Other Alkaloids Phenols Plants Source Classification	Bacterial
Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0126R

Xanthone (Standard) 3 Publications Verification	Infection Classification of Application Fields Guttiferae Phenols Garcinia mangostana Linn. Plants Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Monoamine Oxidase Calcium Channel
Xanthone (Standard) is the analytical standard of Xanthone (HY-N0126). This product is intended for research and analytical applications. Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds .

HY-N14662

Griseolic acid B 7′-Desoxygriseolic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Phosphodiesterase (PDE)
Griseolic acid B (7′-Desoxygriseolic acid) has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with an IC₅₀ of 0.16 μM .

HY-N0113R

Hordenine (Standard) Ordenina (Standard); Peyocactine (Standard)	Cardiovascular Disease Alkaloids other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification	Reference Standards Bacterial Antibiotic
Hordenine (Standard) is the analytical standard of Hordenine. This product is intended for research and analytical applications. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0113BR

Hordenine hydrochloride (Standard) Ordenina hydrochloride (Standard); Peyocactine hydrochloride (Standard)	Coryphantha vivipara var arizonica Structural Classification Alkaloids Monophenols Cactaceae Other Alkaloids Phenols Plants Source Classification	Reference Standards Bacterial
Hordenine (hydrochloride) (Standard) is the analytical standard of Hordenine (hydrochloride). This product is intended for research and analytical applications. Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production[1].

HY-120241

Reticulol K 251-1	Microorganisms Phenols Polyphenols Source Classification	Phosphodiesterase (PDE)
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma .

HY-N14663

Griseolic acid C Dihydrodeoxygriseolic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
Griseolic acid C (Dihydrodeoxygriseolic acid) is an antibiotic. Griseolic acid C can be found in Streptomyces griseoaurantiacus SANK43894. Griseolic acid C has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with an IC₅₀ of 0.12 μM (extracted from rat brain) .

Cat. No.	Product Name	Chemical Structure

HY-B1511S

Cyclic AMP-13C5
Cyclic AMP- ¹³C₅ is a deuterated cyclic AMP.

HY-N0113S

Hordenine-d6
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-108974S

Drotaverine-d10 hydrochloride

Drotaverine-d₁₀ (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects .

HY-B0549S

Flavoxate-d5

Flavoxate-d₅ is deuterium labeled Flavoxate. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

HY-B0549AS

Flavoxate-d4 hydrochloride

Flavoxate-d₄ hydrochloride (Rec-7-0040-d₄) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

Cat. No.	Product Name		Classification

HY-W587488

Adenosine 3′-monophosphate 3′-AMP		Nucleotide Analogs Adenine Nucleotide
Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A_2B receptors .

HY-159857

Gp(2′-5′)Ap sodium Gp(2′-5′)Ap(3′) sodium; 2'5'-GpAp sodium; Guanylyl-(2′→5′)-3′-adenylic acid sodium		Nucleotide Analogs
Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.

Targets Recommended: Adenosine Kinase Adenosine Deaminase Adenosine Receptor IMPDH HCN Channel Cyclic GMP-AMP Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1511G

Cyclic AMP cyclic adenosine monophosphate; adenosine cyclic 3', 5'-monophosphate; cAMP	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Cyclic AMP (GMP) (Cyclic adenosine monophosphate (GMP)) is Cyclic AMP (HY-B1511) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

HY-B0764G

Bucladesine sodium Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (GMP) is a Bucladesine sodium (HY-B0764) produced by using GMP guidelines. Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

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