Phosphodiesterase II, Bovine Spleen  (Synonyms: 3′-Exonuclease)

Phosphodiesterase II (EC 3.1.16.1), namely phosphodiesterase 2, is mainly involved in the hydrolysis of the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), and is often used in biochemical research. Phosphodiesterase II is expressed in a variety of tissues, such as the adrenal medulla, brain, heart, platelets, macrophages and endothelial cells, and is involved in the regulation of many different intracellular processes^[1].

9068-54-6

Solid

White to off-white

[Phosphodiesterase II, Bovine Spleen]

3.1.16.1

≥1.20 U/mg soild

One Unit increases the absorbance at 260 nm by 0.200 in 30 minutes at 37°C, pH 6.5, with an RNA substrate

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chong Zhang, et al. The roles of phosphodiesterase 2 in the central nervous and peripheral systems. Curr Pharm Des. 2015;21(3):274-90.   [Content Brief]