Nitraquazone
Nitraquazone (TVX 2706) is an anti-inflammatory and analgesic agent, belonging to the derivatives of Phenylbutazone (HY-B0230). Nitraquazone inhibits phosphodiesterase and enhances the elevation of intracellular cyclic adenosine monophosphate levels. Nitraquazone can be used in research related to anti-inflammation and analgesia.
For research use only. We do not sell to patients.
- CAS No.: 56739-21-0
- Formula: C16H13N3O4
- Molecular Weight:311.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Nitraquazone significantly enhances effector-induced intracellular cyclic adenosine monophosphate levels in C6-BU-1 rat glioma cells, 108CC15 neuroblastoma×glioma hybrid cells, primary rat embryonic brain cell cultures, and rat cerebral cortical slices, with an EC50 of 0.4 μM in hybrid cells[1].
Nitraquazone inhibits the activities of high-affinity and low-affinity cyclic adenosine monophosphate phosphodiesterases in the homogenate of 108CC15 neuroblastoma×glioma hybrid cells via non-competitive inhibition[1].
Nitraquazone (10 μM) preferentially inhibits the activity of high-affinity cyclic adenosine monophosphate phosphodiesterase in homogenates of rat polymorphonuclear leukocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 56739-21-0
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Molecular Weight 311.29
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Formula C16H13N3O4
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SMILES
O=C(N1CC)N(C2=CC=CC([N+]([O-])=O)=C2)C3=C(C=CC=C3)C1=O
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Synonyms
TVX 2706
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Glaser T, et al. TVX 2706--a new phosphodiesterase inhibitor with antiinflammatory action. Biochemical characterization. Agents Actions. 1984;15(3-4):341-348. [Content Brief]
[2]. Souness JE, et al. Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases. Cell Signal. 1997;9(3-4):227-236. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nitraquazone Related Classifications
HY-106483 Related Classifications
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