PDE1-IN-4
PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.
For research use only. We do not sell to patients.
- CAS No.: 3031349-98-8
- Formula: C33H33N3O4
- Molecular Weight:535.63
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Calcium Channel Isoforms
More
Biological Activity
|
PDE1C 10 ± 3 nM (IC50) |
PDE1A 145 nM (IC50) |
PDE1B 354 nM (IC50) |
PDE4B2 619 nM (IC50) |
PDE4D2 948 nM (IC50) |
PDE10A 1310 nM (IC50) |
PDE5A1 1810 nM (IC50) |
PDE2A 5130 nM (IC50) |
PDE3A >10000 nM (IC50) |
PDE9A2 >10000 nM (IC50) |
PDE1-IN-4 (compound 2g) shows weak inhibition against the hERG channel with an IC50 above 40 μM, indicating that it will not cause cardiotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3031349-98-8
-
Molecular Weight 535.63
-
Formula C33H33N3O4
-
SMILES
CC1=C(C(C2=CC3=C(C=C2)N(N=C3)C)C(C(O[C@@H](C4=CC=CC=C4)C)=O)=C(N1)C)C(O[C@@H](C5=CC=CC=C5)C)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE1-IN-4 Related Classifications
HY-147946 Related Classifications
Powered by Bioz