Gp(2′-5′)Ap sodium
Based on 1 Customer Validation
Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.
For research use only. We do not sell to patients.
- Purity: 98.88%
- Formula: C20H23N10Na3O14P2
- Molecular Weight:758.37
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Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 758.37
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Formula C20H23N10Na3O14P2
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Color White to off-white
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SMILES
O[C@H]1[C@@H](OP(OC[C@@H]2[C@@H](OP(O[Na])(O[Na])=O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3)O2)(O[Na])=O)[C@H](N5C(N=C(N)NC6=O)=C6N=C5)O[C@@H]1CO
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Synonyms
Gp(2′-5′)Ap(3′) sodium; 2'5'-GpAp sodium; Guanylyl-(2′→5′)-3′-adenylic acid sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
H2O : 125 mg/mL (164.83 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Dey RJ, Dey B, Zheng Y, et al. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. Nat Chem Biol. 2017;13(2):210-217. [Content Brief]
[2]. Ablasser A, Goldeck M, Cavlar T, et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013;498(7454):380-384. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3186 mL | 6.5931 mL | 13.1862 mL | 32.9654 mL |
| 5 mM | 0.2637 mL | 1.3186 mL | 2.6372 mL | 6.5931 mL | |
| 10 mM | 0.1319 mL | 0.6593 mL | 1.3186 mL | 3.2965 mL | |
| 15 mM | 0.0879 mL | 0.4395 mL | 0.8791 mL | 2.1977 mL | |
| 20 mM | 0.0659 mL | 0.3297 mL | 0.6593 mL | 1.6483 mL | |
| 25 mM | 0.0527 mL | 0.2637 mL | 0.5274 mL | 1.3186 mL | |
| 30 mM | 0.0440 mL | 0.2198 mL | 0.4395 mL | 1.0988 mL | |
| 40 mM | 0.0330 mL | 0.1648 mL | 0.3297 mL | 0.8241 mL | |
| 50 mM | 0.0264 mL | 0.1319 mL | 0.2637 mL | 0.6593 mL | |
| 60 mM | 0.0220 mL | 0.1099 mL | 0.2198 mL | 0.5494 mL | |
| 80 mM | 0.0165 mL | 0.0824 mL | 0.1648 mL | 0.4121 mL | |
| 100 mM | 0.0132 mL | 0.0659 mL | 0.1319 mL | 0.3297 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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