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製品番号: HY-117232

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KS 501

KS 501 is a potent and selective calmodulin inhibitor. KS 501 inhibits the activation of calmodulin kinase I and II, but has less effect against cyclic adenosine 3’,5’-monophosphate (cyclic AMP)-sensitive kinase. KS 501 inhibits the enzyme through interfering with calmodulin activation rather than through a direct effect on the enzyme. KS 501 can be used for the study of leukemia.

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CAS 番号: 120634-86-8
分子式: C₃₃H₄₈O₁₀
分子量:604.73

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

KS 501 構造式

CAS 番号: 120634-86-8

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Calmodulin アイソフォーム固有の製品をすべて表示 :

体外実験

KS 501 (0-100 μM) inhibits calmodulin-sensitive phosphodiesterase activity in a concentration-dependent manner (IC₅₀ = 0.8 μM)^[1].
KS 501 (0.25-2 μM) shows a decreasing inhibitory effect on phosphodiesterase activity as the concentration of calmodulin increases^[1].
KS 501 (10-40 μM) inhibits calmodulin-dependent synapsin I phosphorylation at 40 μM, while 10 μM has no inhibitory effect on basal activity and instead causes slight stimulation^[1].
KS 501 (10-40 μM) inhibits the phosphorylation of synapsin I at site 1 (a substrate of calmodulin kinase I) and sites 2 and 3 (a substrate of calmodulin kinase II)^[1].
KS 501 (10-40 μM) only partially inhibits synapsin I phosphorylation of cAMP-sensitive protein kinase (PKA)^[1].
KS 501 (0-120 μM) inhibits the proliferation of L1210/S cells (IC₅₀ = 80 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 120634-86-8
分子量 604.73
分子式 C₃₃H₄₈O₁₀
SMILES

CCCCCCCC1=CC(O)=CC(OC(C(C(CCCCCCC)=CC(O)=C2)=C2O[C@@H]3O[C@@]([C@@H]([C@H]3O)O)([H])[C@H](O)CO)=O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hait WN, et al. Effects of KS-501, KS-502 and their enantiomers on calmodulin-sensitive enzyme activity and cellular proliferation. Biochem Pharmacol. 1995 Jun 29;50(1):69-74. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
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- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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KS 501

Calmodulin アイソフォーム固有の製品をすべて表示