KMUP-4
KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K+ channels. KMUP-4 can be used in the study of cardiovascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 864873-81-4
- Formula: C19H23N7O4
- Molecular Weight:413.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
KMUP-4 (1 nM-100 μM) produces concentration-dependent vasorelaxant effects on deendothelial aortas (E2) (pEC50=5.94) and intact endothelial aortas (E+) (PEC50=6.45), indicating that the vasodilatory effect of KMUP-4 is partially dependent on endothelial cells[1]. KMUP-4 (10 μM) shows 56%, 33% and 15% inhibitory activity against PDE3, PDE4 and PDE5 in HUVECs[1]. KMUP-4 (0.1 μM, 18 h) increases significantly the expression of eNOS protein in HUVECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 864873-81-4
-
Molecular Weight 413.43
-
Formula C19H23N7O4
-
SMILES
O=C1C2=C(N(C(N1C)=O)C)N=CN2CCN3CCN(CC3)C4=C(C=CC=C4)[N+]([O-])=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz