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Results for "

suppress+inflammation

" in MedChemExpress (MCE) Product Catalog:

34

Inhibitors & Agonists

5

Peptides

9

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0298A
    Clemastine fumarate
    10+ Cited Publications

    HS-592 fumarate; Meclastine fumarate

    		 Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK Neurological Disease Metabolic Disease
    Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .
    Clemastine fumarate
  • HY-15486
    Salubrinal
    Maximum Cited Publications
    40 Publications Verification

    		 Phosphatase HSV Autophagy Apoptosis Infection Inflammation/Immunology Cancer
    Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis . Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5 .
    Salubrinal
  • HY-101988
    Prostaglandin D2
    4 Publications Verification

    PGD2

    		 Prostaglandin Receptor Endogenous Metabolite Inflammation/Immunology
    Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . Prostaglandin D2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .
    Prostaglandin D2
  • HY-A0183
    Phosphatidylserine
    1 Publications Verification

    Phospholipids, phosphatidylserines; Serine glycerophosphatides

    		 Akt TGF-β Receptor Inflammation/Immunology
    Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses .
    Phosphatidylserine
  • HY-13571A
    Beclometasone dipropionate
    4 Publications Verification

    Beclomethasone dipropionate

    		Glucocorticoid Receptor Reactive Oxygen Species (ROS) NO Synthase Inflammation/Immunology Endocrinology
    Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .
    Beclometasone dipropionate
  • HY-B0298
    Clemastine
    10+ Cited Publications

    HS-592; Meclastine

    		 Histamine Receptor mAChR Autophagy Apoptosis Keap1-Nrf2 p62 mTOR Pyroptosis IKK Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Clemastine (HS-592; Meclastine) is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .
    Clemastine
  • HY-10404
    Dilmapimod
    1 Publications Verification

    SB-681323; GW 681323

    		 p38 MAPK Autophagy Inflammation/Immunology Cancer
    Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.
    Dilmapimod
  • HY-N2963
    Broussonin E
    2 Publications Verification

    		 ERK p38 MAPK JAK STAT TNF Receptor Interleukin Related COX Arginase Inflammation/Immunology
    Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis .
    Broussonin E
  • HY-101988S
    Prostaglandin D2-d4

    PGD2-d4

    		 Prostaglandin Receptor Endogenous Metabolite Inflammation/Immunology
    Prostaglandin D2-d4 is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . Prostaglandin D2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .
    Prostaglandin D2-d4
  • HY-13571AR
    Beclometasone dipropionate (Standard)
    4 Publications Verification

    Beclomethasone dipropionate (Standard)

    		 NO Synthase Glucocorticoid Receptor Reactive Oxygen Species (ROS) Reference Standards Inflammation/Immunology Endocrinology
    Beclometasone dipropionate (Standard) is the analytical standard of Beclometasone dipropionate. This product is intended for research and analytical applications. Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .
    Beclometasone dipropionate (Standard)
  • HY-119678
    Fortunellin
    1 Publications Verification

    		 AMPK Keap1-Nrf2 Cardiovascular Disease Metabolic Disease
    Fortunellin, is a flavonoid, that can be isolated from the fruits of Fortunella margarita (kumquat). Fortunellin exhibits little toxicity to mice and suppresses inflammation and ROS generation in H9C2 cells induced by LPS. Fortunellin protects against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway. Fortunellin can be used for diabetic cardiomyopathy research .
    Fortunellin
  • HY-P10862
    AH-D peptide

    		Exosomes Virus Protease Infection Cancer
    AH-D peptide is a brain-penetrant antiviral agent disrupting highly curved lipid membranes. AH-D peptide exhibits broad-spectrum antiviral activity against ZIKV, Dengue virus, Chikungunya virus, yellow fever virus and Japanese encephalitis virus, with
    IC50
    values of 11.9, 12.5, 35.7, 206 and 136 nM, respectively. AH-D peptide reduces the viral load in the brain, suppresses inflammation, protects neurons, and does not damage the blood brain barrier. AH-D peptide restores antitumor immunity by decreasing circulating PD-L1 + exosomes, reducing intratumoral immunosuppressive cells (regulatory T cells, myeloid-derived suppressor cells), and enhancing T cell function. AH-D peptide inhibits membrane-enveloped viruses and cancer cell metastasis in vivo. AH-D peptide exhibits no immunogenicity and has negligible effects on normal tissues. AH-D peptide can be used for research in Zika virus and other mosquito-borne viruses, cancer immunotherapy and metastasis .
    AH-D peptide
  • HY-101988S1
    Prostaglandin D2-d9

    PGD2-d9

    		 Prostaglandin Receptor Endogenous Metabolite Inflammation/Immunology
    Prostaglandin D2-d9 is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . Prostaglandin D2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .
    Prostaglandin D2-d9
  • HY-P11354
    THR-123

    		TGF-β Receptor Apoptosis Interleukin Related Integrin Cadherin Inflammation/Immunology
    THR-123 is an orally active ALK3 peptide agonist. THR-123 has a relatively weak binding to ALK2, but does not bind to ALK6. THR-123 suppresses inflammation, apoptosis and the epithelial-to-mesenchymal transition program and reverses established fibrosis in five mouse models of acute and chronic renal injury. THR-123 can be used for the study of kidney fibrosis .
    THR-123
  • HY-P1847A
    IKKγ NBD Inhibitory Peptide TFA

    		NF-κB Inflammation/Immunology
    IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .
    IKKγ NBD Inhibitory Peptide TFA
  • HY-N16066
    Candidusin A

    CHNQD-0803

    		 AMPK Apoptosis NF-κB TNF Receptor Inflammation/Immunology
    Candidusin A (CHNQD-0803) (Compound 4) is a AMPK activator with a KD of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells). Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research .
    Candidusin A
  • HY-13571B
    Beclometasone dipropionate monohydrate

    		Glucocorticoid Receptor Reactive Oxygen Species (ROS) NO Synthase Inflammation/Immunology Cancer
    Beclometasone dipropionate monohydrate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma .
    Beclometasone dipropionate monohydrate
  • HY-176301
    Tetranor-PGDM lactone

    Tetranor-prostaglandin D metabolite lactone

    		 Endogenous Metabolite Inflammation/Immunology Endocrinology
    Tetranor-PGDM lactone (Tetranor-prostaglandin D metabolite lactone) is a urinary metabolite of PGD2 (HY-101988). Prostaglandin D2 (PGD2) is one of the most potent endogenous sleep promoting substances. PGD2 plays a protective role by suppressing inflammation .
    Tetranor-PGDM lactone
  • HY-P11354A
    THR-123 TFA

    		TGF-β Receptor Apoptosis Interleukin Related Integrin Cadherin Inflammation/Immunology
    THR-123 TFA is an orally active ALK3 peptide agonist. THR-123 TFA has a relatively weak binding to ALK2, but does not bind to ALK6. THR-123 TFA suppresses inflammation, Apoptosis and the epithelial-to-mesenchymal transition program and reverses established fibrosis in five mouse models of acute and chronic renal injury. THR-123 TFA can be used for the study of kidney fibrosis .
    THR-123 TFA
  • HY-P1847
    IKKγ NBD Inhibitory Peptide

    		NF-κB Cancer
    IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .
    IKKγ NBD Inhibitory Peptide
  • HY-15486R
    Salubrinal (Standard)

    		Phosphatase HSV Autophagy Apoptosis Infection Inflammation/Immunology Cancer
    Salubrinal (Standard) is the analytical standard of Salubrinal. This product is intended for research and analytical applications. Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis . Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5 .
    Salubrinal (Standard)
  • HY-10404A
    Dilmapimod tosylate

    SB-681323 tosylate; GW 681323 tosylate

    		 p38 MAPK Autophagy Inflammation/Immunology Cancer
    Dilmapimod tosylate is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.
    Dilmapimod tosylate
  • HY-10404R
    Dilmapimod (Standard)

    SB-681323 (Standard); GW 681323 (Standard)

    		 Reference Standards p38 MAPK Autophagy Inflammation/Immunology Cancer
    Dilmapimod (Standard) is the analytical standard of Dilmapimod. This product is intended for research and analytical applications. Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.
    Dilmapimod (Standard)
  • HY-124941
    7-Deacetylgedunin

    		Keap1-Nrf2 Reactive Oxygen Species (ROS) Inflammation/Immunology
    7-Deacetylgedunin is an activator of Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1 expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro .
    7-Deacetylgedunin
  • HY-N3289A
    (E)-Methyl 3,4,5-trimethoxycinnamate

    		Others Inflammation/Immunology
    (E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes .
    (E)-Methyl 3,4,5-trimethoxycinnamate
  • HY-101988R
    Prostaglandin D2 (Standard)

    PGD2 (Standard)

    		 Reference Standards Prostaglandin Receptor Endogenous Metabolite Inflammation/Immunology
    Prostaglandin D2 (Standard) is the analytical standard of Prostaglandin D2. This product is intended for research and analytical applications. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . Prostaglandin D2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .
    Prostaglandin D2 (Standard)
  • HY-155780
    Anti-inflammatory agent 52

    		COX Inflammation/Immunology
    Anti-inflammatory agent 52 (compound 7j) is an orally active selective COX-2 inhibitor. Anti-inflammatory agent 52 has anti-HT29 transfer activity, which leads to periodic arrest in G2/M phase. Anti-inflammatory agent 52 has safety, moderate ability to suppress inflammation. Anti-inflammatory agent 52 has a rare property of suppressing the development of tumor in mouse model, showing anti-cancer activity .
    Anti-inflammatory agent 52
  • HY-155781
    Anti-inflammatory agent 53

    		COX Inflammation/Immunology
    Anti-inflammatory agent 53 (compound 7c) is an orally active selective COX-2 inhibitor. Anti-inflammatory agent 52 has anti-HT29 transfer activity, which leads to periodic arrest in S phase and G2/M phase. Anti-inflammatory agent 52 has safety, moderate ability to suppress inflammation. Anti-inflammatory agent 52 has a rare property of suppressing the development of tumor in mouse model, showing anti-cancer activity .
    Anti-inflammatory agent 53
  • HY-B0298AS
    Clemastine-d5 fumarate
    1 Publications Verification

    HS-592-d5 fumarate; Meclastine-d5 fumarate

    		 Isotope-Labeled Compounds Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK Neurological Disease Metabolic Disease
    Clemastine (HS-592; Meclastine)-d5 fumarate is the deuterium labeled Clemastine fumarate. Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .
    Clemastine-d5 fumarate
  • HY-B0298AR
    Clemastine fumarate (Standard)

    HS-592 fumarate (Standard); Meclastine fumarate (Standard)

    		 Reference Standards Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK Neurological Disease Metabolic Disease
    Clemastine (HS-592; Meclastine) fumarate (Standard) is the analytical standard of Clemastine fumarate. This product is intended for research and analytical applications. Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .
    Clemastine fumarate (Standard)
  • HY-N19717
    Bartogenic acid

    		NF-κB SOD Inflammation/Immunology Cancer
    Bartogenic acid is an orally active NF-κB inhibitor, found in Barringtonia racemosa fruits. Bartogenic acid increases catalase, superoxide dismutase (SOD), and glutathione levels. Bartogenic acid inhibits lipid peroxidation and suppresses inflammation markers. Bartogenic acid can be used for the research of ovarian cancer, skin cancer, and inflammatory conditions .
    Bartogenic acid
  • HY-181235
    COX-2/Aromatase-IN-1

    		COX Cytochrome P450 Inflammation/Immunology Cancer
    COX-2/Aromatase-IN-1 is a potent dual inhibitor of COX-2 and aromatase. COX-2/Aromatase-IN-1 can simultaneously inhibit COX-2 and aromatase, significantly suppress inflammation and induce proliferation inhibition of breast cancer cells. COX-2/Aromatase-IN-1 exerts anti-breast cancer and anti-inflammatory effects in the MCF-7 breast cancer cell and carrageenan-induced rat paw edema model. COX-2/Aromatase-IN-1 can be used for the study of inflammation and breast cancer .
    COX-2/Aromatase-IN-1
  • HY-181236
    COX-2/Aromatase-IN-2

    		COX Cytochrome P450 Inflammation/Immunology Cancer
    COX-2/Aromatase-IN-2 is a potent dual inhibitor of COX-2 and aromatase. COX-2/Aromatase-IN-2 can simultaneously inhibit COX-2 and aromatase, suppress inflammation and induce proliferation inhibition of breast cancer cells. COX-2/Aromatase-IN-2 exerts anti-breast cancer and anti-inflammatory effects in the MCF-7 breast cancer cell and carrageenan-induced rat paw edema model. COX-2/Aromatase-IN-2 can be used for the study of inflammation and breast cancer .
    COX-2/Aromatase-IN-2
  • HY-182014
    TLC-2716

    		LXR Cardiovascular Disease Metabolic Disease
    TLC-2716 is an orally available, gut- and liver-restricted inhibitor against LXRα and LXRβ, with EC50 values of 7 nM and 15 nM, respectively. TLC-2716 represses LXRα/β transcriptional activity, downregulates genes involved in lipogenesis, lipid absorption and lipoprotein metabolism, and preserves peripheral reverse cholesterol transport. TLC-2716 reduces lipid accumulation, suppresses inflammation and fibrotic gene expression, enhances triglyceride-rich lipoprotein clearance, and improves glucose homeostasis and insulin sensitivity. TLC-2716 lowers serum and hepatic triglycerides, plasma cholesterol and other atherogenic lipid profiles in experimental models and humanized liver mice. TLC-2716 can be used for the research of dyslipidemia and related cardiometabolic disorders .
    TLC-2716

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