2. Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. Glycosidase PI3K
  4. 1-Deoxynojirimycin

1-デオキシノジリマイシン  (Synonyms: 1-Deoxynojirimycin; Duvoglustat)

製品番号: HY-14860 純度: 98.0%
COA 取扱説明書 Technical Support

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

1-Deoxynojirimycin

1-デオキシノジリマイシン 構造式

CAS 番号 : 19130-96-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 79 在庫あり
Solution
10 mM * 1 mL in Water USD 79 在庫あり
Solid
5 mg $72 在庫あり
10 mg $94 在庫あり
25 mg $198 在庫あり
50 mg $369 在庫あり
100 mg $555 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of 1-Deoxynojirimycin:

1-デオキシノジリマイシン 関連抗体

Top Publications Citing Use of Products

PI3K アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 1
Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
A549 IC50
> 1000 μM
Compound: DNJ
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 21036045]
BGC-823 IC50
> 10 μM
Compound: 1
Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay
Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
Caco-2 IC50
0.06 μM
Compound: 1, DNJ
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
[PMID: 18595718]
HCC1937 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
HCT-116 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
HEK293 IC50
> 100 μM
Compound: dNM, 1-deoxynojirimycin
Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay
Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 18343126]
HEK293 IC50
> 100 μM
Compound: dNM, 1-deoxynojirimycin
Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay
Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 18343126]
HUVEC IC50
2 μM
Compound: 2a
Growth inhibition of HUVEC cells by MTT assay
Growth inhibition of HUVEC cells by MTT assay
[PMID: 18166456]
HepG2 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
MCF7 IC50
> 10 μM
Compound: 1
Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
MOLT-4 CC50
> 100 mg/mL
Compound: 1
Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells
Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells
[PMID: 7608901]
MOLT-4 EC50
> 100 mg/mL
Compound: 1
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells
[PMID: 7608901]
MS-1 IC50
2 μM
Compound: 2a
Growth inhibition of mouse MS1 cells by MTT assay
Growth inhibition of mouse MS1 cells by MTT assay
[PMID: 18166456]
MT4 CC50
> 100 mg/mL
Compound: 1
Concentration giving 50% inhibition of growth of mock-infected MT-4 cells
Concentration giving 50% inhibition of growth of mock-infected MT-4 cells
[PMID: 7608901]
MT4 EC50
> 100 mg/mL
Compound: 1
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells
[PMID: 7608901]
T-cell IC50
25.62 μM
Compound: DNM
Inhibition of CD4 expression in human CD4+ T cells
Inhibition of CD4 expression in human CD4+ T cells
[PMID: 22101135]
体内実験

1-Deoxynojirimycin (Duvoglustat) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect [3].
1-Deoxynojirimycin significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db mice[3]
Dosage: 20, 40, 80 mg/kg
Administration: Intravenously; daily for four weeks
Result: Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.
臨床実験
分子量

163.17

分子式

C6H13NO4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 125 mg/mL (766.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1286 mL 30.6429 mL 61.2858 mL
5 mM 1.2257 mL 6.1286 mL 12.2572 mL
10 mM 0.6129 mL 3.0643 mL 6.1286 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (612.86 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.94%

COA (248 KB) RP-HPLC (195 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.1286 mL 30.6429 mL 61.2858 mL 153.2144 mL
5 mM 1.2257 mL 6.1286 mL 12.2572 mL 30.6429 mL
10 mM 0.6129 mL 3.0643 mL 6.1286 mL 15.3214 mL
15 mM 0.4086 mL 2.0429 mL 4.0857 mL 10.2143 mL
20 mM 0.3064 mL 1.5321 mL 3.0643 mL 7.6607 mL
25 mM 0.2451 mL 1.2257 mL 2.4514 mL 6.1286 mL
30 mM 0.2043 mL 1.0214 mL 2.0429 mL 5.1071 mL
40 mM 0.1532 mL 0.7661 mL 1.5321 mL 3.8304 mL
50 mM 0.1226 mL 0.6129 mL 1.2257 mL 3.0643 mL
60 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5536 mL
80 mM 0.0766 mL 0.3830 mL 0.7661 mL 1.9152 mL
100 mM 0.0613 mL 0.3064 mL 0.6129 mL 1.5321 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Deoxynojirimycin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Deoxynojirimycin19130-96-2DuvoglustatGlycosidasePI3KPhosphoinositide 3-kinasepostprandialbloodglucosediabetesantihyperglycemicanti-obesityantiviralinsulinInhibitorinhibitorinhibit

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製品名:
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製品番号:
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