2. Anti-infection Metabolic Enzyme/Protease Apoptosis
  3. HIV HIV Protease Apoptosis MMP SARS-CoV
  4. Indinavir

Indinavir  (Synonyms: MK-639 free base; L-735524 free base)

Cat. No.: HY-B0689 Pureté: 99.96%
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SDS
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Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor.

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Indinavir

Indinavir Chemical Structure

CAS No. : 150378-17-9

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
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100 mg   Obtenir un devis  

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Based on 8 publication(s) in Google Scholar

Other Forms of Indinavir:

Indinavir Related Antibodies

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Voir tous les produits spécifiques à Isoform HIV:

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HIV HIV-1 HIV-2

Voir tous les produits spécifiques à Isoform MMP:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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Description

Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor[1][2][3][4].

IC50 & Target

HIV-1

 

MMP-2

 

In Vitro

Indinavir (0-50 μM; 18 h) blocks lymphocyte cell cycle in G0/G1 phase in PBMCs cells and impairs lymphoproliferative responses[1].
Indinavir (40 μM-40 nM; 5 days) inhibits cell invasion and (40 μM-40 nM; 48 h) MMPs-2 activation of the Huh7 and SK-HEP-1 hepatocarcinoma cells in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Indinavir Related Antibodies

Cell Viability Assay[1]

Cell Line: PBMCs (from healthy and HIV-infected volunteers)
Concentration: 0-50 µM
Incubation Time: 18 h (pretreatment; stimulation with anti-CD3 for an additional 48 hours)
Result: Blocked anti-CD3-induced cell-cycle progression in a dose-dependent manner.
Resulted in dose-dependent reduction of lymphoproliferative responses.

Cell Invasion Assay[2]

Cell Line: Huh7 and SK-HEP-1 cells
Concentration: 40 µM-40 nM
Incubation Time: 5 days
Result: Reduced ability to invade an in vitro constituted extracellular matrix for both cell lines treated compared with the untreated cells.

Western Blot Analysis[2]

Cell Line: Huh7 and SK-HEP-1 cells
Concentration: 40 µM-40 nM
Incubation Time: 48 h
Result: Blocked the conversion of latent MMP-2 to its 62/64-kDa active form.
In Vivo

Indinavir (70 mg/kg; i.g.; once a day for 3 weeks) inhibits the growth of hepatocarcinoma cells in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice(s.c. into Huh7 and SK-HEP-1 cells)[2].
Dosage: 70 mg/kg
Administration: Oral gavage; once a day for 3 weeks.
Result: Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.
Masse moléculaire

613.79

Formule

C36H47N5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](C[C@H](O)CN(CCN(CC1=CN=CC=C1)C2)[C@@H]2C(NC(C)(C)C)=O)CC3=CC=CC=C3)N[C@H]4C(C=CC=C5)=C5C[C@H]4O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : ≥ 100 mg/mL (162.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6292 mL 8.1461 mL 16.2922 mL
5 mM 0.3258 mL 1.6292 mL 3.2584 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 99.96%

SDS (393 KB)

COA (249 KB) HNMR (210 KB) RP-HPLC (243 KB) LCMS (94 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6292 mL 8.1461 mL 16.2922 mL 40.7305 mL
5 mM 0.3258 mL 1.6292 mL 3.2584 mL 8.1461 mL
10 mM 0.1629 mL 0.8146 mL 1.6292 mL 4.0731 mL
15 mM 0.1086 mL 0.5431 mL 1.0861 mL 2.7154 mL
20 mM 0.0815 mL 0.4073 mL 0.8146 mL 2.0365 mL
25 mM 0.0652 mL 0.3258 mL 0.6517 mL 1.6292 mL
30 mM 0.0543 mL 0.2715 mL 0.5431 mL 1.3577 mL
40 mM 0.0407 mL 0.2037 mL 0.4073 mL 1.0183 mL
50 mM 0.0326 mL 0.1629 mL 0.3258 mL 0.8146 mL
60 mM 0.0272 mL 0.1358 mL 0.2715 mL 0.6788 mL
80 mM 0.0204 mL 0.1018 mL 0.2037 mL 0.5091 mL
100 mM 0.0163 mL 0.0815 mL 0.1629 mL 0.4073 mL
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Indinavir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indinavir150378-17-9MK-639L-735524MK639MK 639L735524L 735524HIVHIV ProteaseApoptosisMMPSARS-CoVHuman immunodeficiency virusMatrix metalloproteinasesSARS coronavirusCD4 T cellsPBMChepatocarcinomasHuh7SK-HEP-1Inhibitorinhibitorinhibit

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