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Anti-spasmodic,

" in MedChemExpress (MCE) Product Catalog:

51

Inhibitors & Agonists

15

Natural
Products

7

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2604
    Loureirin C

    		Bacterial Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Loureirin C has anti-bacterial, anti-spasmodic, anti-inflammatory, analgesic, anti-diabetic, and anti-tumor activities .
    Loureirin C
  • HY-N0820
    Catalpol
    Maximum Cited Publications
    6 Publications Verification

    Catalpinoside

    		 HBV Infection Neurological Disease Inflammation/Immunology Cancer
    Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .
    Catalpol
  • HY-N5086
    Picroside IV

    		HBV Infection Neurological Disease Metabolic Disease Inflammation/Immunology
    Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .
    Picroside IV
  • HY-13557
    Ascomycin
    Maximum Cited Publications
    6 Publications Verification

    Immunomycin; FR-900520; FK520

    		 FKBP Parasite Fungal Antibiotic Infection Neurological Disease Inflammation/Immunology
    Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .
    Ascomycin
  • HY-133153S
    Fenpiverinium-d3 bromide

    		Isotope-Labeled Compounds Neurological Disease
    Fenpiverinium-d3 (bromide) is a deuterium labeled Fenpiverinium bromide. Fenpiverinium bromide has anti-cholinergic and anti-spasmodic effects[1].
    Fenpiverinium-d3 bromide
  • HY-N2071
    Cedrol
    1 Publications Verification

    (+)-Cedrol; α-Cedrol

    		 Cytochrome P450 Fungal Infection Inflammation/Immunology Cancer
    Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes . Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, insecticidal, and anti-fungal activities .
    Cedrol
  • HY-B0326
    Alibendol

    		Others Endocrinology
    Alibendol is an antispasmodic,choleretic, and cholekinetic.
    Alibendol
  • HY-U00195
    Piperylone

    PR66

    		 Others Neurological Disease
    Piperylone can be used as an antispasmodic.
    Piperylone
  • HY-W201842
    Octamylamine

    		mAChR Neurological Disease
    Octamylamine is an anticholinergic and antispasmodic agent .
    Octamylamine
  • HY-B0549AS
    Flavoxate-d4 hydrochloride

    		mAChR Neurological Disease
    Flavoxate-d4 (hydrochloride) (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate Hydrochloride is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic[1][2].
    Flavoxate-d4 hydrochloride
  • HY-N4113
    Glycycoumarin

    		Keap1-Nrf2 AMPK Cancer
    Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .
    Glycycoumarin
  • HY-12770
    Mebeverine alcohol

    Mebeverine metabolite Mebeverine alcohol

    		 Drug Metabolite Neurological Disease
    Mebeverine alcohol is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
    Mebeverine alcohol
  • HY-122086
    Prifinium bromide

    		mAChR Neurological Disease
    Prifinium bromide is antimuscarinic agent with antispasmodic, antiemetic effect .
    Prifinium bromide
  • HY-12771
    O-desmethyl Mebeverine acid

    Mebeverine metabolite O-desmethyl Mebeverine acid

    		 Drug Metabolite Neurological Disease
    O-desmethyl Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
    O-desmethyl Mebeverine acid
  • HY-105652
    Ambucetamide

    		Others Neurological Disease
    Ambucetamide is an antispasmodic agent. Ambucetamide alleviates menstrual pain .
    Ambucetamide
  • HY-I0637
    Isovanillin

    3-Hydroxy-4-methoxybenzaldehyde

    		 Others Neurological Disease Metabolic Disease
    Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .
    Isovanillin
  • HY-12769S
    Mebeverine acid-d5

    		Drug Metabolite Neurological Disease
    Mebeverine acid-d5 is the deuterium labeled Mebeverine Acid; Mebeverine Acid is a metabolite of Mebeverine, that is an antispasmodic.
    Mebeverine acid-d5
  • HY-116755
    Tiropramide

    CR 605

    		 Others Others
    Tiropramide is an antispasmodic agent that plays important roles in spasmodic pain of the hepatobiliary and urinary tract .
    Tiropramide
  • HY-107349
    Fenoverine

    Spasmopriv

    		 Calcium Channel Neurological Disease
    Fenoverine (Spasmopriv) is an antispasmodic agent and inhibits calcium channel currents . Fenoverine induces rhabdomyolysis .
    Fenoverine
  • HY-105771
    Parapenzolate bromide

    		mAChR Neurological Disease
    Parapenzolate bromide, an antispasmodic, is an orally active mAChR antagonist. Parapenzolate bromide is an anticholinergic agent .
    Parapenzolate bromide
  • HY-N2842
    α-Amyrin acetate

    		Others Inflammation/Immunology
    α-Amyrin acetate, a natural triterpenoid, has anti-inflammatory activity, antispasmodic profile and the relaxant effect .
    α-Amyrin acetate
  • HY-12769
    Mebeverine acid

    Mebeverine metabolite Mebeverine acid

    		 Drug Metabolite Neurological Disease
    Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine .
    Mebeverine acid
  • HY-122520
    Fentonium bromide

    		Others Neurological Disease
    Fentonium bromide is an anti-ulcerogenic, anticholinergic and antispasmodic agent. Fentonium bromide can be used in the research of neurological conditions .
    Fentonium bromide
  • HY-118524A
    Dipiproverine hydrochloride

    LD-935

    		 Others Neurological Disease
    Dipiproverine (hydrochloride) is the hydrochloride form of Dipiproverine (HY-118524). Dipiproverine (hydrochloride) is an alpha-amino acid ester, an antispasmodic compound, which is used as an anticholinergic agent .
    Dipiproverine hydrochloride
  • HY-100562
    Flopropione

    		5-HT Receptor COMT Neurological Disease
    Flopropione is a 5-HT receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor . Flopropione also as an antispasmodic agent .
    Flopropione
  • HY-111025
    Ectylurea

    		Others Neurological Disease
    Ectylurea，a N-acylurea，can be used in studies of tension and anxiety symptoms, has no effect on the autonomic nervous system, and has no convulsive, analgesic or antispasmodic activity in animals .
    Ectylurea
  • HY-I0637S
    Isovanillin-d3

    3-Hydroxy-4-methoxybenzaldehyde-d3

    		 Isotope-Labeled Compounds
    Isovanillin-d3 is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].
    Isovanillin-d3
  • HY-121020
    Arcapillin

    		Phosphatase Neurological Disease
    Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin has antispasmodic activity. Arcapillin also has moderate PTP1B inhibitory activity .
    Arcapillin
  • HY-107349S
    Fenoverine-d8

    Spasmopriv-d8

    		 Calcium Channel Neurological Disease
    Fenoverine-d8 is the deuterium labeled Fenoverine[1]. Fenoverine (Spasmopriv) is an antispasmodic agent and inhibits calcium channel currents[2]. Fenoverine induces rhabdomyolysis[3].
    Fenoverine-d8
  • HY-N2746
    7-O-Geranylscopoletin

    7-Geranyloxy-6-methoxycoumarin

    		 Others Neurological Disease Metabolic Disease
    7-O-Geranylscopoletin is a coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purposes such as chronic rheumatism, paralysis, antispasmodic, stimulant and hemiplegia .
    7-O-Geranylscopoletin
  • HY-N2050
    1,3,5,8-Tetrahydroxyxanthone
    1 Publications Verification

    Desmethylbellidifolin
    1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Swertia chirata. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity .
    1,3,5,8-Tetrahydroxyxanthone
  • HY-113123
    LysoPC(14:0/0:0)

    		Endogenous Metabolite Neurological Disease Metabolic Disease
    LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .
    LysoPC(14:0/0:0)
  • HY-B1394
    Khellin

    Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects .
    Khellin
  • HY-119918
    Cycrimine

    		mAChR Neurological Disease
    Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder .
    Cycrimine
  • HY-108964
    Carvone

    		Bacterial Infection Neurological Disease Inflammation/Immunology
    Carvone is a ketone monoterpene found mostly in the essential oils from plants of the genus Mentha. Carvone is widely used in the pharmaceutical industry, cosmetics and agriculture. Carvone has such effects as antimicrobial, antioxidant, anti-inflammatory, antispasmodic, antinociceptive, anticonvulsant .
    Carvone
  • HY-B2078A
    Eprazinone dihydrochloride

    Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen .
    Eprazinone dihydrochloride
  • HY-B1806A
    Tridihexethyl chloride

    Pathilon chloride

    		 mAChR Neurological Disease Inflammation/Immunology
    Tridihexethyl (Pathilon) chloride is an orally active anticholinergic agent and mAChR antagonist, shows activities of antimuscarinic and anticholinergic. Tridihexethyl chloride shows pronounced antispasmodic and antisecretory effects on the gastrointestinal tract. Tridihexethyl chloride can be used in studies of peptic ulcer disease and acquired nystagmus .
    Tridihexethyl chloride
  • HY-16489
    Terodiline

    		Potassium Channel mAChR Calcium Channel Metabolic Disease
    Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence .
    Terodiline
  • HY-B0549A
    Flavoxate hydrochloride

    Rec-7-0040; DW61

    		 Phosphodiesterase (PDE) Calcium Channel mAChR Neurological Disease
    Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections .
    Flavoxate hydrochloride
  • HY-108974
    Drotaverine hydrochloride

    		Phosphodiesterase (PDE) Calcium Channel
    Drotaverine (hydrochloride) is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.
    Drotaverine hydrochloride
  • HY-B0549
    Flavoxate

    Rec-7-0040 free base; DW61 free base

    		 Phosphodiesterase (PDE) Calcium Channel mAChR Neurological Disease
    Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections .
    Flavoxate
  • HY-12752
    Alimemazine

    Trimeprazine

    		 Histamine Receptor Neurological Disease Inflammation/Immunology
    Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties .
    Alimemazine
  • HY-B0267C
    (R)-Oxybutynin

    Aroxybutynin

    		 mAChR Neurological Disease
    (R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction .
    (R)-Oxybutynin
  • HY-14621
    Zingerone
    2 Publications Verification

    Vanillylacetone; Gingerone

    		 NF-κB Metabolic Disease Inflammation/Immunology Cancer
    Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells .
    Zingerone
  • HY-108974S
    Drotaverine-d10 hydrochloride

    		Isotope-Labeled Compounds Phosphodiesterase (PDE) Calcium Channel
    Drotaverine-d10 (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects[1][2].
    Drotaverine-d10 hydrochloride
  • HY-B1339
    Dicyclomine hydrochloride

    Dicycloverine hydrochloride

    		 mAChR Neurological Disease
    Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively . Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo .
    Dicyclomine hydrochloride
  • HY-B1339A
    Dicyclomine

    Dicycloverine

    		 mAChR
    Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively . Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo .
    Dicyclomine
  • HY-N11706
    β-Cedrene

    (+)-β-Cedrene

    		 Fungal Infection Inflammation/Immunology
    β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM .
    β-Cedrene
  • HY-B0267B
    (R)-Oxybutynin hydrochloride

    Aroxybutynin hydrochloride

    		 mAChR Neurological Disease
    (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction . (R)-Oxybutynin (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (R)-Oxybutynin hydrochloride
  • HY-B1339AS
    Dicyclomine-d4

    Dicycloverine-d4

    		 mAChR
    Dicyclomine-d4 is the deuterium labeled Dicyclomine[1]. Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[2]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[3].
    Dicyclomine-d4

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