2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Prifinium bromide

Prifinium bromide is an anticholinergic drug with anticholinergic and antispasmodic activities, and it exhibits oral activity. Prifinium bromide competitively antagonizes cholinergic receptors and relieves symptoms of spasm or hypermotility in the digestive and urinary tracts, with its anticholinergic activity representing the core mechanism underlying the inhibition of bladder smooth muscle contraction. Prifinium bromide can be used in research related to spasms and diverticular disease.

For research use only. We do not sell to patients.

Prifinium bromide

Prifinium bromide Chemical Structure

CAS No. : 4630-95-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
Solid
100 mg In-stock
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Prifinium bromide Related Antibodies

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Description

Prifinium bromide is an anticholinergic drug with anticholinergic and antispasmodic activities, and it exhibits oral activity. Prifinium bromide competitively antagonizes cholinergic receptors and relieves symptoms of spasm or hypermotility in the digestive and urinary tracts, with its anticholinergic activity representing the core mechanism underlying the inhibition of bladder smooth muscle contraction. Prifinium bromide can be used in research related to spasms and diverticular disease[1][2][3].
In Vitro

Prifinium bromide inhibits carbamoylcholine chloride (HY-B1208)-induced contraction of isolated guinea pig detrusor muscle, but exerts almost no effect on contractions induced by electrical stimulation, KCl or BaCl2[1].
Prifinium bromide exhibits anticholinergic activity in isolated guinea pig ileum, with a relative potency of 0.45 compared with Atropine (HY-B1205)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Prifinium bromide Related Antibodies
Molecular Weight

386.37

Formula

C22H28BrN
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1[N+](CC)(CC/C1=C(C2=CC=CC=C2)\C3=CC=CC=C3)CC.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (258.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5882 mL 12.9410 mL 25.8819 mL
5 mM 0.5176 mL 2.5882 mL 5.1764 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5882 mL 12.9410 mL 25.8819 mL 64.7048 mL
5 mM 0.5176 mL 2.5882 mL 5.1764 mL 12.9410 mL
10 mM 0.2588 mL 1.2941 mL 2.5882 mL 6.4705 mL
15 mM 0.1725 mL 0.8627 mL 1.7255 mL 4.3137 mL
20 mM 0.1294 mL 0.6470 mL 1.2941 mL 3.2352 mL
25 mM 0.1035 mL 0.5176 mL 1.0353 mL 2.5882 mL
30 mM 0.0863 mL 0.4314 mL 0.8627 mL 2.1568 mL
40 mM 0.0647 mL 0.3235 mL 0.6470 mL 1.6176 mL
50 mM 0.0518 mL 0.2588 mL 0.5176 mL 1.2941 mL
60 mM 0.0431 mL 0.2157 mL 0.4314 mL 1.0784 mL
80 mM 0.0324 mL 0.1618 mL 0.3235 mL 0.8088 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6470 mL
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Prifinium bromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prifinium4630-95-9mAChRMuscarinic acetylcholine receptordistal colonguinea-pig detrusor musclemuscarinic acetylcholine receptorsdigestive tractsproximal colonurinary tractsdiverticular diseaseguinea-pig ileumurinary bladderdetrusor muscleInhibitorinhibitorinhibit

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