(R)-Oxybutynin  (Synonyms: Aroxybutynin)

(R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction^[1][2][3].

Muscarinic receptor, mAChR^[1][2]

The metabolism of Oxybutynin is stereoselective and it is extensively metabolized primarily by cytochrome P450 3A4 to form NDO. (R)-Oxybutynin has lower plasma concentrations than the other enantiomer^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

357.49

C₂₂H₃₁NO₃

119618-21-2

CCN(CC)CC#CCOC([C@@](C1CCCCC1)(C2=CC=CC=C2)O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Smith ER, et al. Comparison of the antimuscarinic and antispasmodic actions of racemic oxybutynin and desethyloxybutynin and their enantiomers with those of racemic terodiline. Arzneimittelforschung. 1998 Oct;48(10):1012-8.  [Content Brief]

  [2]. Siddiqui MA, et al. Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs. 2004;64(8):885-912.  [Content Brief]

  [3]. Zobrist RH, et al. Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharm Res. 2001 Jul;18(7):1029-34.  [Content Brief]