(R)-Oxybutynin
(R)-Oxybutynin (Aroxybutynin), an enantiomer of Oxybutynin, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin exhibits antispasmodic and anticholinergic activities, and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used in the research of urinary incontinence caused by neurogenic bladder dysfunction.
For research use only. We do not sell to patients.
- CAS No.: 119618-21-2
- Formula: C22H31NO3
- Molecular Weight:357.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
(R)-Oxybutynin (96 h) shows comparable in vitro permeation capacity across heat-separated human cadaver epidermal membranes to its S-enantiomer, with a total mean cumulative permeation amount of 139 μg/cm2[2].
(R)-Oxybutynin is the enantiomer of Oxybutynin (HY-B0267) with higher antimuscarinic activity. It is 12- to 88-fold more potent than the S-enantiomer at M1, M2, and M3 receptor subtypes, and shows a slight preference for M3[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 119618-21-2
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Molecular Weight 357.49
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Formula C22H31NO3
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SMILES
CCN(CC)CC#CCOC([C@@](C1CCCCC1)(C2=CC=CC=C2)O)=O
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Synonyms
Aroxybutynin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Smith ER, et al. Comparison of the antimuscarinic and antispasmodic actions of racemic oxybutynin and desethyloxybutynin and their enantiomers with those of racemic terodiline. Arzneimittel-Forschung. 1998 Oct;48(10):1012-8. [Content Brief]
[2]. Zobrist RH, et al. Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharmaceutical research. 2001 Jul;18(7):1029-34. [Content Brief]
[4]. Siddiqui MA, et al. Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs. 2004;64(8):885-912. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-Oxybutynin Related Classifications
HY-B0267C Related Classifications
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Keywords
- (R)-Oxybutynin
- 119618-21-2
- Aroxybutynin
- mAChR
- M2 muscarinic receptor subtype
- smooth muscle relaxant
- neurogenic detrusor overactivity
- hypoglossal motor nucleus
- urinary incontinence
- muscarinic receptors
- M1 muscarinic receptor subtype
- overactive bladder
- muscarinic receptor antagonist
- obstructive sleep apnea
- Inhibitor
- inhibitor
- inhibit