119618-21-2
Chemical Structure
(R)-Oxybutynin
Synonym(s): Aroxybutynin
- CAS No.: 119618-21-2
- Formula:C22H31NO3
- Molecular Weight:357.49
IUPAC Name: (S)-2-(tert-butoxycarbonyl)pyrazolidine-3-carboxylic acid
InChIKey: XIQVNETUBQGFHX-QFIPXVFZSA-N
SMILES: CCN(CC)CC#CCOC([C@@](C1CCCCC1)(C2=CC=CC=C2)O)=O
Biological Activity: (R)-Oxybutynin (Aroxybutynin), an enantiomer of Oxybutynin, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin exhibits antispasmodic and anticholinergic activities, and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used in the research of urinary incontinence caused by neurogenic bladder dysfunction[1][2][3][4].
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(R)-Oxybutynin | (R)-Oxybutynin (Aroxybutynin), an enantiomer of Oxybutynin, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin exhibits antispasmodic and anticholinergic activities, and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used in the research of urinary incontinence caused by neurogenic bladder dysfunction. | |||||||||||||||||||||
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(R)-Oxybutynin-d10 | (R)-Oxybutynin-d10 (Aroxybutynin-d10) is deuterium labeled (R)-Oxybutynin. (R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction. | |||||||||||||||||||||
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References
- [1]. Smith ER, et al. Comparison of the antimuscarinic and antispasmodic actions of racemic oxybutynin and desethyloxybutynin and their enantiomers with those of racemic terodiline. Arzneimittel-Forschung. 1998 Oct;48(10):1012-8. [Content Brief]
- [2]. Zobrist RH, et al. Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharmaceutical research. 2001 Jul;18(7):1029-34. [Content Brief]
- [3]. Horner RL, et al. Mechanisms of upper airway muscle control in sleep reveal therapeutic targets for obstructive sleep apnea. American journal of respiratory cell and molecular biology. 2026 Jul 01;74(7):847-857.
- [4]. Siddiqui MA, et al. Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs. 2004;64(8):885-912. [Content Brief]
