Fenoverine-d8
Based on 1 Customer Validation
Fenoverine-d8 is the deuterium labeled Fenoverine. Fenoverine (Spasmopriv) is an orally active and powerful anti-spasmodic drug. Fenoverine reduces calcium ion influx by suppressing voltage dependent calcium channels. Fenoverine has antiemetic, analgesic, and antidiarrheal effects. Fenoverine induces rhabdomyolysis. Fenoverine can be used to study smooth muscle overexcitation related conditions such as gastrointestinal spasms.
For research use only. We do not sell to patients.
- Purity: 98.88%
- Formula: C26H17D8N3O3S
- Molecular Weight:467.61
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 37561-27-6
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Appearance Solid
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Molecular Weight 467.61
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Formula C26H17D8N3O3S
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Color White to off-white
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SMILES
O=C(N1C2=C(C=CC=C2)SC3=CC=CC=C13)CN4C([2H])([2H])C([2H])([2H])N(CC5=CC=C(OCO6)C6=C5)C([2H])([2H])C4([2H])[2H]
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Synonyms
Spasmopriv-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (213.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. J Mironneau, et al. Fenoverine inhibition of calcium channel currents in single smooth muscle cells from rat portal vein and myometrium. Br J Pharmacol. 1991 Sep;104(1):65-70. [Content Brief]
[2]. Chung-Wen Chen, et al. Rhabdomyolysis induced by fenoverine: a case report and literature review. Acta Neurol Taiwan. 2005 Sep14(3):143-6. [Content Brief]
[3]. Hu OY, et al. Determination of fenoverine, a modulator of smooth muscle motility, in capsules and in human plasma: application to dosage form stability and a pilot study in humans. J Pharm Sci. 1992 Jan;81(1):91-3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1385 mL | 10.6927 mL | 21.3853 mL | 53.4634 mL |
| 5 mM | 0.4277 mL | 2.1385 mL | 4.2771 mL | 10.6927 mL | |
| 10 mM | 0.2139 mL | 1.0693 mL | 2.1385 mL | 5.3463 mL | |
| 15 mM | 0.1426 mL | 0.7128 mL | 1.4257 mL | 3.5642 mL | |
| 20 mM | 0.1069 mL | 0.5346 mL | 1.0693 mL | 2.6732 mL | |
| 25 mM | 0.0855 mL | 0.4277 mL | 0.8554 mL | 2.1385 mL | |
| 30 mM | 0.0713 mL | 0.3564 mL | 0.7128 mL | 1.7821 mL | |
| 40 mM | 0.0535 mL | 0.2673 mL | 0.5346 mL | 1.3366 mL | |
| 50 mM | 0.0428 mL | 0.2139 mL | 0.4277 mL | 1.0693 mL | |
| 60 mM | 0.0356 mL | 0.1782 mL | 0.3564 mL | 0.8911 mL | |
| 80 mM | 0.0267 mL | 0.1337 mL | 0.2673 mL | 0.6683 mL | |
| 100 mM | 0.0214 mL | 0.1069 mL | 0.2139 mL | 0.5346 mL |
Fenoverine-d8 Related Classifications
HY-107349S Related Classifications
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