1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. mAChR
    Calcium Channel
  3. Terodiline

Terodiline 

Cat. No.: HY-16489
Handling Instructions

Terodiline is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline also is a Ca2+ blocker. Terodiline acts as a treatment for urinary frequency and urge incontinence.

For research use only. We do not sell to patients.

Terodiline Chemical Structure

Terodiline Chemical Structure

CAS No. : 15793-40-5

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Description

Terodiline is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline also is a Ca2+ blocker. Terodiline acts as a treatment for urinary frequency and urge incontinence[1].

IC50 & Target

mAChR[1]
Ca2+ channel[1]

In Vivo

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fmale or male Hartley guinea pigs (200-600 g)[1]
Dosage: 80 mg/kg
Administration: Administered S.C.
Result: Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
Molecular Weight

281.44

Formula

C20H27N

CAS No.
SMILES

CC(NC(C)(C)C)CC(C1=CC=CC=C1)C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Terodiline
Cat. No.:
HY-16489
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