1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. mAChR
    Calcium Channel
  3. Terodiline hydrochloride

Terodiline hydrochloride 

Cat. No.: HY-16489A
Handling Instructions

Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence.

For research use only. We do not sell to patients.

Terodiline hydrochloride Chemical Structure

Terodiline hydrochloride Chemical Structure

CAS No. : 7082-21-5

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Estimated Time of Arrival: December 31
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Description

Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1].

IC50 & Target

mAChR[1]
Ca2+ channel[1]

In Vivo

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1].

Animal Model: Fmale or male Hartley guinea pigs (200-600 g)[1]
Dosage: 80 mg/kg
Administration: Administered S.C.
Result: Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
Molecular Weight

317.90

Formula

C₂₀H₂₈ClN

CAS No.

7082-21-5

SMILES

CC(NC(C)(C)C)CC(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TerodilinemAChRCalcium ChannelMuscarinic acetylcholine receptorCa2+ channelsCa channelsmuscarinicreceptorCa2+blockerurinaryfrequencyurgeincontinenceantianginalInhibitorinhibitorinhibit

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Product name:
Terodiline hydrochloride
Cat. No.:
HY-16489A
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