1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Dicyclomine hydrochloride

Dicyclomine hydrochloride (Synonyms: Dicycloverine hydrochloride)

Cat. No.: HY-B1339 Purity: 99.32%
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Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.

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Dicyclomine hydrochloride Chemical Structure

Dicyclomine hydrochloride Chemical Structure

CAS No. : 67-92-5

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Based on 1 publication(s) in Google Scholar

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Description

Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].

IC50 & Target

Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane)
Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane[1]

In Vivo

Dicyclomine hydrochloride (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice[2].
Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks[3].

Animal Model: C57Bl/6 mice[1]
Dosage: 2.0, 4.0, and 8.0 mg/kg
Administration: Intraperitoneal injection; daily; 7 days
Result: Produced impairments due to actions of the agent outside of the hippocampus.
Molecular Weight

345.95

Formula

C₁₉H₃₆ClNO₂

CAS No.

67-92-5

SMILES

O=C(C1(C2CCCCC2)CCCCC1)OCCN(CC)CC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

DicyclomineDicycloverinemAChRMuscarinic acetylcholine receptorantispasmodicBacteriumAlzheimer’s disease,irritablebowelsyndromeIBSanticholinergicInhibitorinhibitorinhibit

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Dicyclomine hydrochloride
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