67-92-5
67-92-5
Chemical Structure
Dicyclomine hydrochloride
Synonym(s): Dicycloverine hydrochloride
- CAS No.: 67-92-5
- Formula:C19H36ClNO2
- Molecular Weight:345.95
IUPAC Name: 2-(diethylamino)ethyl [1,1'-bi(cyclohexane)]-1-carboxylate hydrochloride
InChIKey: GUBNMFJOJGDCEL-UHFFFAOYSA-N
SMILES: O=C(C1(C2CCCCC2)CCCCC1)OCCN(CC)CC.[H]Cl
Biological Activity: Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Dicyclomine hydrochloride | 98.0% | Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo. | ||||||||||||||||||||
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Dicyclomine hydrochloride (Standard) | ≥98% | Dicyclomine (hydrochloride) (Standard) is the analytical standard of Dicyclomine (hydrochloride). This product is intended for research and analytical applications. Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo. | ||||||||||||||||||||
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Dicyclomine-d4 hydrochloride | Dicyclomine-d4 hydrochloride (Dicycloverine-d4 hydrochloride) is the deuterium labeled Dicyclomine hydrochloride (HY-B1339). Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo. | |||||||||||||||||||||
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Cyprodenate | 98.0% | Cyprodenate is an orally active and blood-brain barrier-penetrant stimulant. Cyprodenate can be labeled with 14C. Cyprodenate can be used in the research of psychiatric disorders. | ||||||||||||||||||||
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Rociverine | Rociverine is an anticholinergic compound with smooth muscle relaxant activity. Rociverine showed different binding modes in five cloned muscarinic receptors. The cis stereoisomer of Rociverine showed a higher affinity change compared to the trans stereoisomer. The (1R,2R) configuration of Rociverine showed significantly higher affinity, even up to 240 times. The (1S,2S) configuration of Rociverine is very important for binding selectivity. | |||||||||||||||||||||
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Dihexyverine hydrochloride | Dihexyverine hydrochloride is a compound belonging to the amino alcohol ester class. Dihexyverine hydrochloride possesses anticholinergic, smooth muscle relaxant, antihistaminic, and antiemetic effects. Dihexyverine hydrochloride can also shorten the duration of labor. Dihexyverine hydrochloride can be used in research related to gastrointestinal spasms, obstetrics, and other fields. | |||||||||||||||||||||
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As-358 | As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM. | |||||||||||||||||||||
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As-358 hydrochloride | As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety. | |||||||||||||||||||||
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Isomylamine hydrochloride | Isomylamine hydrochloride is a spasmolytic and smooth muscle relaxant that can be utilized in relevant research or chemical synthesis. | |||||||||||||||||||||
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Dicyclomine | Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo. | |||||||||||||||||||||
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Decahydro-1,4-naphthalenedicarboxylic acid (mixture of isomers) | Decahydro-1,4-naphthalenedicarboxylic acid (mixture of isomers) (Decahydro-1,4-naphthalenedicarboxylic Acid) is a metal-organic framework (MOF). | |||||||||||||||||||||
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1-(7-Hydroxy-4-methyloctyl) 1,2-cyclohexanedicarboxylate | 1-(7-Hydroxy-4-methyloctyl) 1,2-cyclohexanedicarboxylate is a metabolite of di (isononyl) cyclohexane-1,2-dicarboxylate (DINCH) , an alternative for phthalate plasticizers. It can be used as a biomarker of exposure to DINCH. | |||||||||||||||||||||
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1,2-Cyclohexanedicarboxylic acid mono 4-methyl-7-carboxy-heptyl ester | 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester is a secondary oxidized metabolite of di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) , an alternative for phthalate plasticizer. | |||||||||||||||||||||
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References
- [1]. J Pavía,et al. Pharmacological Characterization and Distribution of Muscarinic Receptors in Human Placental Syncytiotrophoblast Brush-Border and Basal Plasma Membranes. Eur J Pharmacol. . 1997 Feb 12;320(2-3):209-14. [Content Brief]
- [2]. Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020. [Content Brief]
