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Coumarin Derivative

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0281
    Daphnetin
    Maximum Cited Publications
    7 Publications Verification

    7,8-DihydroxyCoumarin

    		 EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite Cardiovascular Disease Inflammation/Immunology Cancer
    Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
    Daphnetin
  • HY-W027544
    MCA

    7-MethoxyCoumarin-4-acetic acid

    		 Fluorescent Dye Others
    MCA (7-Methoxycoumarin-4-acetic acid) is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
    MCA
  • HY-N6856
    4-Hydroxycoumarin

    		Bacterial Endogenous Metabolite Infection Cancer
    4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    4-Hydroxycoumarin
  • HY-N7085
    Citropten

    5,7-DimethoxyCoumarin; Limettin

    		 Environmental Pollutants ERK p38 MAPK JNK Neurological Disease Inflammation/Immunology Cancer
    Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .
    Citropten
  • HY-N4288
    4-Methylesculetin
    3 Publications Verification

    		 Glutathione Peroxidase Cathepsin Phosphatase Inflammation/Immunology Cancer
    4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .
    4-Methylesculetin
  • HY-121930
    Coumarin 6H

    		Fluorescent Dye Inflammation/Immunology
    Coumarin 6H, a Coumarin (HY-N0709) derivative, is a laser dye. The fluorescence emission of Coumarin 6H can be enhanced by hydrogen bonding interactions .
    Coumarin 6H
  • HY-A0145
    Phenprocoumon

    		VD/VDR Others Cancer
    Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
    Phenprocoumon
  • HY-101887
    Calcein Blue
    2 Publications Verification

    		 Fluorescent Dye Others
    Calcein Blue, a membrane-impermeant fluorescent dye, is a coumarin derivative that contains an iminodiacetic acid structure. Calcein Blue is also a metallofluorochromic indicator .
    Calcein Blue
  • HY-Y1298
    Methyl acetylacetate
    1 Publications Verification

    Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives. Methyl acetoacetate can be used in the study of inflammatory diseases .
    Methyl acetylacetate
  • HY-N5092
    7-Methylcoumarin

    		Reactive Oxygen Species (ROS) Cytochrome P450 Metabolic Disease
    7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .
    7-Methylcoumarin
  • HY-D1085
    AMCA-X SE

    		Fluorescent Dye Others
    AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .
    AMCA-X SE
  • HY-W072009
    5,7-Dihydroxycoumarin

    		Bacterial Infection
    5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-dihydroxycoumarin displays antibacterial characteristics with an MIC value in the range of 1000 mg/mL to >1000 mg/mL. Some 5,7-dihydroxycoumarin derivatives have antioxidant properties .
    5,7-Dihydroxycoumarin
  • HY-N4286
    4-Methyldaphnetin

    		Apoptosis Cancer
    4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation .
    4-Methyldaphnetin
  • HY-109714
    3,4-Benzocoumarin

    		Drug Derivative Inflammation/Immunology
    3,4-Benzocoumarin is a kind of the expanded structure of coumarin derivatives.Coumarin is a chemical compound in the benzopyrone chemical class that can be found in many natural species. Coumarins possess variety of biological activities and unique photophysical properties . 3,4-Benzocoumarin, a AOH‐like compound , has the sensibility of the antibody with an IC50 of 919.2 ng/mL .
    3,4-Benzocoumarin
  • HY-129605
    Ferulenol

    		Oxidative Phosphorylation Mitochondrial Metabolism Infection
    Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action .
    Ferulenol
  • HY-W014081
    Ethyl 3-coumarincarboxylate

    Ethyl 2-oxo-2H-chromene-3-carboxylate

    		 Drug Derivative Others
    Ethyl 3-coumarincarboxylate is a coumarin derivative. Ethyl 3-coumarincarboxylate can be used as a pseudo-template to give a molecularly imprinted polymer (MIP) that has a fairly specific recognition capability for aflatoxins .
    Ethyl 3-coumarincarboxylate
  • HY-D0128
    4-Methylherniarin

    7-Methoxy-4-methylCoumarin

    		 Bacterial Infection
    4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label, has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 values of 11.76 μg/ml and 13.47 μg/ml .
    4-Methylherniarin
  • HY-N0947
    (-)-Anomalin

    (-)-Praeruptorin B

    		 Others Inflammation/Immunology
    (-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of Angelica anomala .
    (-)-Anomalin
  • HY-D0039
    3-Cyanoumbelliferone

    		Fluorescent Dye Others
    3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM .
    3-Cyanoumbelliferone
  • HY-128410
    4-Phenyl-7,8-dihydroxycoumarin

    		COMT Inflammation/Immunology
    4-Phenyl-7,8-dihydroxycoumarin is a coumarin derivative and can be used for bronchiectasiss research .
    4-Phenyl-7,8-dihydroxycoumarin
  • HY-156305
    Coumarin-C2-exo-BCN

    		Fluorescent Dye Others
    Coumarin-C2-exoBCN is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-exoBCN contains the lyophilic bidentate macrocyclic ligand exo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to generate stable triazoles under catalyst-free conditions.
    Coumarin-C2-exo-BCN
  • HY-76779
    4-(Chloromethyl)-7-hydroxycoumarin

    		Drug Derivative Cancer
    4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .
    4-(Chloromethyl)-7-hydroxycoumarin
  • HY-149828
    MTHFD2-IN-4

    		Methylenetetrahydrofolate Dehydrogenase (MTHFD) Cancer
    MTHFD2-IN-4, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 can be used in research of cancer .
    MTHFD2-IN-4
  • HY-N8712
    Umckalin

    		p38 MAPK JNK ERK TNF Receptor Interleukin Related PI3K Akt Inflammation/Immunology
    Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE2 production. Umckalin can be used for the research of chronic inflammatory diseases .
    Umckalin
  • HY-N7085R
    Citropten (Standard)

    5,7-DimethoxyCoumarin (Standard); Limettin (Standard)

    		 ERK JNK p38 MAPK Reference Standards Neurological Disease Inflammation/Immunology Cancer
    Citropten (Standard) is the analytical standard of Citropten. This product is intended for research and analytical applications. Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .
    Citropten (Standard)
  • HY-N6856R
    4-Hydroxycoumarin (Standard)

    		Reference Standards Bacterial Endogenous Metabolite Infection Cancer
    4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    4-Hydroxycoumarin (Standard)
  • HY-N11791
    Qianhucoumarin B

    		Others Others
    Qianhucoumarin B is a coumarin derivative. Qianhucoumarin B can be isolated from from the traditional Chinese medicine Qianhu, roots of Peucedanum praeruptorum .
    Qianhucoumarin B
  • HY-156304
    Coumarin-C2-TCO

    		Fluorescent Dye Others
    Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
    Coumarin-C2-TCO
  • HY-N6657
    7-Hydroxy-4-methyl-8-nitrocoumarin

    		Drug Derivative Cancer
    7-Hydroxy-4-methyl-8-nitrocoumarin is a coumarin derivative .
    7-Hydroxy-4-methyl-8-nitrocoumarin
  • HY-121770
    Rutarin

    		Drug Derivative Parasite Fungal Infection
    Rutarin is a Coumarin (HY-N0709) derivative with antimalarial and antifungal activities. Rutarin inhibits Plasmodium falciparum with an IC50 of 88 μg/mL. Rutarin also inhibits Coniophora cerebella .
    Rutarin
  • HY-N0187A
    4-Methylumbelliferone sodium salt
    Maximum Cited Publications
    7 Publications Verification

    Hymecromone sodium salt; 4-MU sodium salt

    		 Biochemical Assay Reagents Cancer
    4-Methylumbelliferone (sodium salt) is a coumarin derivative. 4-Methylumbelliferone (sodium salt) can be used as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action. 4-Methylumbelliferone (sodium salt) inhibits hyaluronan production in vitro. 4-Methylumbelliferone (sodium salt) can be studied in ovarian cancer research .
    4-Methylumbelliferone sodium salt
  • HY-N8791
    Qianhucoumarin G

    		Others Others
    Qianhucoumarin G is a natural coumarin derivative found in Ligustici Radix .
    Qianhucoumarin G
  • HY-W011435
    Ethyl 6-bromo-3-coumarincarboxylate

    		Drug Derivative Others
    Ethyl 6-bromo-3-coumarincarboxylate is a coumarin derivative .
    Ethyl 6-bromo-3-coumarincarboxylate
  • HY-149828A
    MTHFD2-IN-4 sodium

    		Methylenetetrahydrofolate Dehydrogenase (MTHFD) Cancer
    MTHFD2-IN-4 sodium, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 sodium can be used in research of cancer .
    MTHFD2-IN-4 sodium
  • HY-146305
    α-Glucosidase-IN-4

    		Glycosidase Infection Cardiovascular Disease Others Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
    α-Glucosidase-IN-4 is a reversible and mixed type α-glucosidase inhibitor with an IC50 of 12.98 μM, a KI of 27.02 μM, and a KIS of 13.65 μM, respectively .
    α-Glucosidase-IN-4
  • HY-D0092
    7-Ethoxy-4-methylcoumarin

    		Cytochrome P450 Others
    7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6 .
    7-Ethoxy-4-methylcoumarin
  • HY-N8849
    4-Methyl-6,7-methylenedioxycoumarin

    4-Methylayapin

    		 Fungal Infection
    4-Methyl-6,7-methylenedioxycoumarin (4-Methylayapin) is a Coumarin (HY-N0709) derivative. 4-Methyl-6,7-methylenedioxycoumarin exhibits antifungal activity against Pythium sp. .
    4-Methyl-6,7-methylenedioxycoumarin
  • HY-179212
    (±)-Coladonin

    		Drug Derivative Fungal Infection
    (±)-Coladonin (Compound (±)-12), Coumarin (HY-N0709) derivative, is an antifungal agent. (±)-Coladonin exhibits potent inhibitory effect on the plant pathogenic fungus Botrytis cinerea. (±)-Coladonin is mainly used for the research on the prevention and control of gray mold disease in crops .
    (±)-Coladonin
  • HY-177798
    AChE-IN-98

    		Cholinesterase (ChE) Neurological Disease
    AChE-IN-98 (Compound 26) is an AChE inhitibor, with an IC50 value of 7.3 μM for ee AChE. AChE-IN-98 is also a Coumarin (HY-N0709) derivative. AChE-IN-98 can be used in the research of Alzheimer's disease .
    AChE-IN-98
  • HY-N16544
    Perforatin A

    O-Methylalloptaeroxylin

    		 Others Others
    Perforatin A (O-Methylalloptaeroxylin) (Compound 1) is a natural product that can be found in C. gracilis.
    Perforatin A
  • HY-119292
    AP2238

    		Cholinesterase (ChE) Amyloid-β Neurological Disease
    AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with Ki values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease .
    AP2238
  • HY-N0281R
    Daphnetin (Standard)

    7,8-DihydroxyCoumarin (Standard)

    		 Reference Standards EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite Inflammation/Immunology Cancer
    Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
    Daphnetin (Standard)
  • HY-N0947R
    (-)-Anomalin (Standard)

    (-)-Praeruptorin B (Standard)

    		 Reference Standards Others Inflammation/Immunology
    (-)-Anomalin (Standard) is the analytical standard of (-)-Anomalin. This product is intended for research and analytical applications. (-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of Angelica anomala .
    (-)-Anomalin (Standard)
  • HY-163397
    Antibacterial agent 196

    		Fungal Infection
    Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
    Antibacterial agent 196
  • HY-156303
    Coumarin-PEG2-TCO

    		Fluorescent Dye Others
    Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
    Coumarin-PEG2-TCO
  • HY-156309
    Coumarin-PEG8-tetrazine

    		Fluorescent Dye Others
    Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Coumarin-PEG8-tetrazine
  • HY-156306
    Coumarin-PEG3-TCO

    		Fluorescent Dye Others
    Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
    Coumarin-PEG3-TCO
  • HY-155095
    DNA polymerase-IN-4

    		Others Infection
    DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC50 value of 134.22 μM .
    DNA polymerase-IN-4
  • HY-N3422A
    (rac)-Khellactone

    		Drug Isomer Cancer
    (rac)-Khellactone is the racemic form of Khellactone. (rac)-Khellactone is a type of coumarin, and its derivatives are expected to be used in the research of the anti-cancer field .
    (rac)-Khellactone
  • HY-A0145R
    Phenprocoumon (Standard)

    		VD/VDR Reference Standards Others Cancer
    Phenprocoumon (Standard) is the analytical standard of Phenprocoumon. This product is intended for research and analytical applications. Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
    Phenprocoumon (Standard)

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