Antileishmanial agent-27
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties.
For research use only. We do not sell to patients.
- Formula: C24H16BrNO3S2
- Molecular Weight:510.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Leishmania |
Antileishmanial agent-27 (compound 7j) exhibits low cytotoxicity toward murine macrophage RAW 264.7, with an IC50 value of 210±17 μM[1].
Antileishmanial agent-27 stabilizes LdArgRS better than L-Arg and ATP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 510.42
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Formula C24H16BrNO3S2
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SMILES
O=C1OC2=CC(OCC3=CC=C(Br)C=C3)=CC=C2C(CSC4=NC5=C(S4)C=CC=C5)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-27 Related Classifications
HY-163457 Related Classifications
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