AP2238
AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with Ki values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 553681-56-4
- Formula: C26H25NO4
- Molecular Weight:415.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hAChE 21.7 μM (Ki) |
hBCHE 48.9 μM (Ki) |
Chemical Information
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CAS No. 553681-56-4
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Molecular Weight 415.48
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Formula C26H25NO4
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SMILES
O=C1C(C2=CC=C(CN(C)CC3=CC=CC=C3)C=C2)=CC4=CC(OC)=C(OC)C=C4O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Piazzi L, et al. 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. J Med Chem. 2003 Jun 5;46(12):2279-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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