553681-56-4
553681-56-4
Chemical Structure
AP2238
- CAS No.: 553681-56-4
- Formula:C26H25NO4
- Molecular Weight:415.48
IUPAC Name: 3-(4-((benzyl(methyl)amino)methyl)phenyl)-6,7-dimethoxy-2H-chromen-2-one
InChIKey: KXMCSAUVAHKCOR-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(CN(C)CC3=CC=CC=C3)C=C2)=CC4=CC(OC)=C(OC)C=C4O1
Biological Activity: AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with Ki values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease[1].
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AP2238 | AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with Ki values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Piazzi L, et al. 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. J Med Chem. 2003 Jun 5;46(12):2279-82. [Content Brief]
