1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. Ferulenol

Ferulenol 

Cat. No.: HY-129605
Handling Instructions

Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action.

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Ferulenol Chemical Structure

Ferulenol Chemical Structure

CAS No. : 6805-34-1

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Description

Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action[1][2][3].

In Vitro

Ferulenol inhibits the oxidative phosphorylation process by interacting with adenine nucleotide translocase (ANT) and the complex II of the respiratory chain. At low concentrations, ferulenol inhibited ATP synthesis by inhibition of the adenine nucleotide translocase without limitation of mitochondrial respiration. At higher concentrations, ferulenol inhibited oxygen consumption. Ferulenol caused specific inhibition of succinate ubiquinone reductase without altering succinate dehydrogenase activity of the complex II[1]. Ferulenol inhibits succinate ubiquinone reductase(SQR) activity in a concentration-dependent manner and is as effective as thenoyltrifluoroacetone (TTFA)[1].

Molecular Weight

366.49

Formula

C₂₄H₃₀O₃

CAS No.

6805-34-1

SMILES

O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(O)C2=CC=CC=C2O1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FerulenolMitochondrial MetabolismsuccinateubiquinonereductaseantimycobacterialhaemorrhagicmitochondrialdysfunctionInhibitorinhibitorinhibit

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