4-Methylumbelliferone sodium salt
Based on 8 publication(s) in Google Scholar
4-Methylumbelliferone (sodium salt) is a coumarin derivative. 4-Methylumbelliferone (sodium salt) can be used as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action. 4-Methylumbelliferone (sodium salt) inhibits hyaluronan production in vitro. 4-Methylumbelliferone (sodium salt) can be studied in ovarian cancer research.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 5980-33-6
- Formula: C10H7NaO3
- Molecular Weight:198.15
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 4-Methylumbelliferone sodium salt
More- J Transl Med. 2025 Feb 24;23(1):224. [Abstract]
- Int J Biol Macromol. 2025 Apr 28;310(Pt 4):143599. [Abstract]
- Int J Biol Macromol. 2022 Dec 1;222(Pt B):2225-2243. [Abstract]
- Cell Rep. 2024 Feb 16;43(2):113808. [Abstract]
- Commun Biol. 2026 Apr 8;9(1):764. [Abstract]
- Int J Mol Sci. 2025 Aug 7;26(15):7637. [Abstract]
- Pancreatology. 2024 Aug;24(5):719-731. [Abstract]
- bioRxiv. 2024 September 07.
Customer Validation & Images
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WB
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Gel Electrophoresis
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Cell Imaging/Staining
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IF
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Cell Imaging/Staining
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 5980-33-6
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Appearance Solid
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Molecular Weight 198.15
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Formula C10H7NaO3
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Color Off-white to light yellow
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SMILES
O=C1C=C(C2=CC=C(C=C2O1)O[Na])C
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Synonyms
Hymecromone sodium salt; 4-MU sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (8)
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Journal Impact Factor
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Most Recent
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J Transl Med
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction. [Abstract]2025 Feb 24;23(1):224. PMID: 39994656
4-Methylumbelliferone sodium salt purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Feb 24;23(1):224. [Abstract]
Representative western blots and statistical analysis of CD68, OPN, ARG1, CD206, collagen I, and αSMA protein expression levels in ITIH5 overexpression and control co-culture systems treated with different concentrations of 4-Methylumbelliferone (0-1 mM, 24 h).
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Int J Biol Macromol
2025 Apr 28;310(Pt 4):143599. PMID: 40306505 -
Int J Biol Macromol
HIF1α lactylation enhances KIAA1199 transcription to promote angiogenesis and vasculogenic mimicry in prostate cancer. [Abstract]2022 Dec 1;222(Pt B):2225-2243. PMID: 36209908 -
Cell Rep
UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis. [Abstract]2024 Feb 16;43(2):113808. PMID: 38367236 -
Commun Biol
2026 Apr 8;9(1):764. PMID: 41951812 -
Int J Mol Sci
Dual Effect of 4-Methylumbelliferone on INS1E Cells: Enhancing Migration and Glucose-Stimulated Insulin Secretion. [Abstract]2025 Aug 7;26(15):7637. PMID: 40806765
4-Methylumbelliferone sodium salt purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Aug 7;26(15):7637. [Abstract]
Electrophoresis analysis and staining of HA extracted from conditioned medium by the same cells, in the presence or absence of 4-Methylumbelliferone (4MU) and HYAL (6 U/mL). The analyzed samples include: (1) INS1E/SVF control, (2) INS1E/SVF treated with 4-Methylumbelliferone (4MU), (3) INS1E/SVF treated with HYAL (6 U/mL).
4-Methylumbelliferone sodium salt purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Aug 7;26(15):7637. [Abstract]
Phase contrast Images of INS1E pseudo-islets treated or untreated with 4-Methylumbelliferone (4MU) for 24 h.
4-Methylumbelliferone sodium salt purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Aug 7;26(15):7637. [Abstract]
Immunofluorescence analysis of INS1E cells cultured in 2D conditions, with or without 4-Methylumbelliferone (4MU) treatment, stained with anti-insulin antibody, DAPI, and Phalloidin.
4-Methylumbelliferone sodium salt purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Aug 7;26(15):7637. [Abstract]
Phase contrast images of INS1E cells grown in 2D conditions, with or without 0.250 mM 4-Methylumbelliferone (4MU) cultivated on a tissue culture plate.
4-Methylumbelliferone sodium salt purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Aug 7;26(15):7637. [Abstract]
Quantification of basal insulin secretion in INS1E cells grown in 2D and 3D conditions, with or without 0.250 mM of 4-Methylumbelliferone (4MU). Insulin levels were normalized to the total protein content (mg) of cell extracts.
4-Methylumbelliferone sodium salt purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Aug 7;26(15):7637. [Abstract]
Cell viability assessment (MTS assay) of INS1E cells treated with different concentrations of 4-Methylumbelliferone (4MU) (0.5–0.075 mM) for 48 h.
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Pancreatology
Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation. [Abstract]2024 Aug;24(5):719-731. PMID: 38719756 -
Solvent & Solubility
H2O : ≥ 100 mg/mL (504.67 mM)
DMSO : 50 mg/mL (252.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Pibuel, M. A., et al., (2021). 4-Methylumbelliferone as a potent and selective antitumor drug on a glioblastoma model. Glycobiology, 31(1), 29–43. [Content Brief]
[2]. Rodrigues, A. C., (2015). Celluclast and Cellic® CTec2: Saccharification/fermentation of wheat straw, solid-liquid partition and potential of enzyme recycling by alkaline washing. Enzyme and microbial technology, 79-80, 70–77. [Content Brief]
[3]. Lokman, N. A., et al., (2019). 4-Methylumbelliferone Inhibits Cancer Stem Cell Activation and Overcomes Chemoresistance in Ovarian Cancer. Cancers, 11(8), 1187. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.0467 mL | 25.2334 mL | 50.4668 mL | 126.1670 mL |
| 5 mM | 1.0093 mL | 5.0467 mL | 10.0934 mL | 25.2334 mL | |
| 10 mM | 0.5047 mL | 2.5233 mL | 5.0467 mL | 12.6167 mL | |
| 15 mM | 0.3364 mL | 1.6822 mL | 3.3645 mL | 8.4111 mL | |
| 20 mM | 0.2523 mL | 1.2617 mL | 2.5233 mL | 6.3084 mL | |
| 25 mM | 0.2019 mL | 1.0093 mL | 2.0187 mL | 5.0467 mL | |
| 30 mM | 0.1682 mL | 0.8411 mL | 1.6822 mL | 4.2056 mL | |
| 40 mM | 0.1262 mL | 0.6308 mL | 1.2617 mL | 3.1542 mL | |
| 50 mM | 0.1009 mL | 0.5047 mL | 1.0093 mL | 2.5233 mL | |
| 60 mM | 0.0841 mL | 0.4206 mL | 0.8411 mL | 2.1028 mL | |
| 80 mM | 0.0631 mL | 0.3154 mL | 0.6308 mL | 1.5771 mL | |
| 100 mM | 0.0505 mL | 0.2523 mL | 0.5047 mL | 1.2617 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
4-Methylumbelliferone sodium salt Related Classifications
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