7-Ethoxy-4-methylcoumarin
Based on 1 Customer Validation
7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 87-05-8
- Formula: C12H12O3
- Molecular Weight:204.22
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP1A1 |
CYP2B4 |
CYP2B6 |
Chemical Information
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CAS No. 87-05-8
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Appearance Solid
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Molecular Weight 204.22
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Formula C12H12O3
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Color White to off-white
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SMILES
O=C1C=C(C)C2=CC=C(OCC)C=C2O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (244.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kuhn UD, et al. Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin. Exp Toxicol Pathol. 1998 Sep;50(4-6):491-6. [Content Brief]
[2]. Liu J, et al. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry. 2016 Apr 5;55(13):1997-2007. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8967 mL | 24.4834 mL | 48.9668 mL | 122.4170 mL |
| 5 mM | 0.9793 mL | 4.8967 mL | 9.7934 mL | 24.4834 mL | |
| 10 mM | 0.4897 mL | 2.4483 mL | 4.8967 mL | 12.2417 mL | |
| 15 mM | 0.3264 mL | 1.6322 mL | 3.2645 mL | 8.1611 mL | |
| 20 mM | 0.2448 mL | 1.2242 mL | 2.4483 mL | 6.1209 mL | |
| 25 mM | 0.1959 mL | 0.9793 mL | 1.9587 mL | 4.8967 mL | |
| 30 mM | 0.1632 mL | 0.8161 mL | 1.6322 mL | 4.0806 mL | |
| 40 mM | 0.1224 mL | 0.6121 mL | 1.2242 mL | 3.0604 mL | |
| 50 mM | 0.0979 mL | 0.4897 mL | 0.9793 mL | 2.4483 mL | |
| 60 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
| 80 mM | 0.0612 mL | 0.3060 mL | 0.6121 mL | 1.5302 mL | |
| 100 mM | 0.0490 mL | 0.2448 mL | 0.4897 mL | 1.2242 mL |
7-Ethoxy-4-methylcoumarin Related Classifications
HY-D0092 Related Classifications
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