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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
106 Results for "
EGFR antibody
" in MedChemExpress (MCE) Product Catalog:
Products (106)
106 Results for "EGFR antibody" in MCE Product Catalog:
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Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity .
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Depatuxizumab mafodotin (ABT-414) is an antibody-drug conjugate (ADC). Depatuxizumab mafodotin specifically targets the epidermal growth factor receptor (EGFR). Depatuxizumab mafodotin can be used in the study of glioma, head and neck squamous cell carcinoma, non-small cell lung cancer, epidermoid carcinoma of the skin, and squamous cell carcinoma of the tongue .
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1 Cited Publications
Cat. No.: HY-P80116
Synonyms: Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody;
Cell growth inhibiting protein 40 antibody;
Cell proliferation inducing protein 61 antibody;
EGF R antibody;
EGFR antibody;
EGFR_HUMAN antibody;
Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody;
Epidermal growth factor receptor antibody;
erb-b2 receptor tyrosine kinase 1 antibody;
ERBB antibody;
ERBB1 antibody;
Errp antibody;
HER1 antibody;
mENA antibody;
NISBD2 antibody;
Oncogen ERBB antibody;
PIG61 antibody;
Proto-oncogene c-ErbB-1 antibody;
Receptor tyrosine protein kinase ErbB 1 antibody;
Receptor tyrosine-protein kinase ErbB-1 antibody;
SA7 antibody;
Species antigen 7 antibody;
Urogastrone antibody;
v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody;
wa2 antibody;
Wa5 antibody
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MC-Gly-Gly-Phe-Gly-PAB-PNP is a linker for synthesis anti-human EGFR antibody agent conjugate .
Cat. No.: HY-P99406
CAS No.: 2213450-26-9
Synonyms: MCLA 158
Cat. No.: HY-164702
Synonyms: Izalontamab Brengitecan
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BL-B01D1 (Izalontamab Brengitecan) is a bispecific antibody-drug conjugate (ADC) targeting EGFR and HER3, formed by conjugating the EGFR/HER3 bispecific antibody Izalontamab (HY-P99676) to a novel TOP-I inhibitor payload Deruxtecan 2-hydroxypropanamide (HY-153891) via a cleavable linker (Mc-Gly-Gly-Phe-Gly). BL-B01D1 binds to EGFR and HER3 on the surface of tumor cells, mediates endocytosis and releases the payload, inhibits topoisomerase I, blocks DNA replication and RNA synthesis, and disrupts DNA structure. BL-B01D1 induces cell cycle S-phase arrest, apoptosis, antibody-dependent cell-mediated cytotoxicity, and tumor cell death. BL-B01D1 can be used for cancer research .
Cat. No.: HY-P99676
CAS No.: 2559704-24-2
Synonyms: SI-B001; BL-B01D1 antibody
Cat. No.: HY-171135
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Cetuximab MMAE is an antibody-drug conjugate (ADC) targeting EGFR, formed by the random conjugation of the Cetuximab (HY-P9905) antibody and VcMMAE (HY-15575) via reduced interchain cysteines. Cetuximab MMAE binds to EGFR, blocks ligand interactions, inhibits downstream signal transduction, mediates receptor internalization, and delivers MMAE to induce G2/M phase cell cycle arrest, inhibit microtubule polymerization, interfere with mitosis, and exert radiosensitizing effects. Cetuximab MMAE limits the toxicity of free MMAE to EGFR-expressing cells and circumvents EGFR resistance mechanisms. Cetuximab MMAE is applicable to research related to EGFR + tumors .
Cat. No.: HY-171265
Synonyms: MRG003
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Becotatug vedotin (MRG003) is an Antibody-Drug Conjugate (ADC) that consists of an anti-EGFR humanized IgG1 monoclonal antibody Becotatug (HY-P990049) and MMAE (HY-15162). These two parts are connected through a valine-citrulline (valine-citrulline) linker, where the linker and MMAE constitute the ADC's Drug-Linker conjugate VcMMAE (HY-15575). Becotatug vedotin can be used for the research of cancer, such as squamous cell carcinomas of the head and neck, nasopharyngeal carcinoma .
Cat. No.: HY-P99455
CAS No.: 2437210-79-0
Synonyms: EMB-01
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Cat. No.: HY-P99849
CAS No.: 1471999-69-5
Synonyms: ABT-806
Cat. No.: HY-P9S0008
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Cat. No.: HY-P9964
CAS No.: 906805-06-9
Synonyms: 11F8; IMC-11F8; LY3012211
Cat. No.: HY-171124
Synonyms: AZD9592
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Tilatamig samrotecan (AZD9592) is an anti-EGFR/c-MET antibody-drug conjugate (ADC). Tilatamig samrotecan consists of an anti-EGFR/c-MET antibody with the drug-linker conjugate being AZ14170133 (HY-145399) (a topoisomerase I (TOP1i) inhibitor payload). Tilatamig samrotecan induces multiple DNA damage response pathway markers (like ATM, ATR, γH2AX). Tilatamig samrotecan selectively binds to EGFR and c-MET, delivering the cytotoxic payload. Tilatamig samrotecan exerts anti-tumor activity in vivo. Tilatamig samrotecan can be used for non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) research .
Cat. No.: HY-P990957
CAS No.: 2764727-44-6
Synonyms: BCA-101; FMAB2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
