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Nimotuzumab

(Synonyms: h-R3)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Nimotuzumab is a humanized IgG1 monoclonal antibody targeting EGFR with a KD of 0.21 nM. Nimotuzumab is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab, a strong antitumor agent, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).

For research use only. We do not sell to patients.

  • Purity: 96.80%
  • CAS No.: 780758-10-3
  • Molecular Weight:147.58 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Nimotuzumab
  • Experimental Validation Results for Nimotuzumab
  • Experimental Validation Results for Nimotuzumab
  • Nimotuzumab Chemical Structure
    Nimotuzumab Chemical Structure
CAS No.: 780758-10-3
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized EGFR vIII Protein, Human (HEK293, His, HY-P70189) can bind Nimotuzumab. The EC50 for this effect is 19 ng/mL.

  • 1/16

    Flow Cytometry analysis of A431 cells labelling ERBB1/EGFR/HER1 (red) with Nimotuzumab (anti-ERBB1/EGFR/HER1) (HY-P9968). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.

  • Nimotuzumab Chemical Structure
    1/16
  • Nimotuzumab
  • Immobilized EGFR vIII Protein, Human (HEK293, His, HY-P70189) can bind Nimotuzumab. The EC50 for this effect is 19 ng/mL.
  • Flow Cytometry analysis of A431 cells labelling ERBB1/EGFR/HER1 (red) with Nimotuzumab (anti-ERBB1/EGFR/HER1) (HY-P9968). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.