1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Nimotuzumab

Nimotuzumab 

Cat. No.: HY-P9968

Nimotuzumab is a humanized IgG1 monoclonal antibody targeting EGFR with a KD of 0.21 nM. Nimotuzumab is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab, a strong antitumor drug, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).

For research use only. We do not sell to patients.

Nimotuzumab Chemical Structure

Nimotuzumab Chemical Structure

CAS No. : 780758-10-3

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1 mg USD 560 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
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Description

Nimotuzumab is a humanized IgG1 monoclonal antibody targeting EGFR with a KD of 0.21 nM. Nimotuzumab is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab, a strong antitumor drug, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC)[1][2].

In Vitro

Nimotuzumab (10 μg/mL; 24 hours) induces significant downregulation of CD16 on NK cells[1].
Nimotuzumab (10 μg/mL; 48 hours) induces the upregulation of PD-L1 molecule on DCs when co-cultured with the NK: DC: HNSCC cells[1].
The intrinsic properties of Nimotuzumab requires bivalent binding (i.e., binding with both antibody arms to two targets simultaneously) for stable attachment to cellular surface, which leads to Nimotuzumab selectively binding to cells that express moderate to high EGFR levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
SMILES

[Nimotuzumab]

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Keywords:

NimotuzumabEGFREpidermal growth factor receptorErbB-1HER1IgG1antibodyADCCCDCInhibitorinhibitorinhibit

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Nimotuzumab
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