2. Antibody-drug Conjugate/ADC Related MAPK/ERK Pathway GPCR/G Protein
  3. Drug-Linker Conjugates for ADC Ras
  4. Z56-L23

Z56-L23 is a conjugate of RAS-targeting ADC cytotoxic payload-linker with anti-tumor activity. Z56-L23 can be conjugated with HER3 antibody, EGFR antibody or EGFRxHER3 bispecific antibody to form intact antibody-drug conjugates (ADCs). ADC molecules related to Z56-L23 effectively inhibit the proliferation of tumor cells and also significantly suppress tumor growth in xenograft mouse models. Z56-L23 can be used in the research of pancreatic cancer.

For research use only. We do not sell to patients.

Z56-L23

Z56-L23 Chemical Structure

CAS No. : 3077488-78-6

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Z56-L23 Related Antibodies

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K-Ras H-Ras N-Ras Ras

  • Biological Activity

  • Purity & Documentation

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Description

Z56-L23 is a conjugate of RAS-targeting ADC cytotoxic payload-linker with anti-tumor activity. Z56-L23 can be conjugated with HER3 antibody, EGFR antibody or EGFRxHER3 bispecific antibody to form intact antibody-drug conjugates (ADCs). ADC molecules related to Z56-L23 effectively inhibit the proliferation of tumor cells and also significantly suppress tumor growth in xenograft mouse models. Z56-L23 can be used in the research of pancreatic cancer[1].

In Vitro

Z56-L23 conjugated to HER3 antibody, EGFR antibody, or EGFRxHER3 bispecific antibody forms ADCs with high SEC monomer purity (97.70%-98.62%) and DAR values ranging from 4.17 to 7.93[1].
Z56-L23-HER3 ADC and Z56-L23-EGFR ADC potently inhibit the proliferation of NCI-H441 and AsPC-1 cells, with IC50 values ranging from 0.03 nM to 1.60 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z56-L23 Related Antibodies
In Vivo

Z56-L23-HER3 ADC and Z56-L23-EGFR ADC (5-10 mg/kg; intravenous injection; once weekly ×2) exhibit potent anti-tumor activity in NCI-H441 xenograft mice, with tumor growth inhibition (TGI) ranging from 99.15% to 124.66%, and only mild to moderate body weight changes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with Non-small cell lung cancer[1]
Dosage: 10 mg/kg (Z56-L23-HER3; Z56-L23-EGFR); 5 mg/kg (Z56-L23-EGFRxHER3)
Administration: i.v.; qw ×2
Result: Induced a tumor growth inhibition rate (TGI) of 99.15% and a mouse body weight change of 2.37% (Z56-L23-HER3).
Induced a TGI of 113.57% and a mouse body weight change of 8.38% (Z56-L23-EGFR).
Induced a TGI of 124.66% and a mouse body weight change of 1.24% (Z56-L23-EGFRxHER3).
Molecular Weight

1908.28

Formula

C98H136N15O22S+
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)NC(CCN1C(C=CC1=O)=O)=O)NCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC2=CC=C(C[N+]3(CC#CC4=C[C@]([C@]5=C(CC(C)(COC([C@H]6NN7CCC6)=O)C)C8=C(C=CC(C9=CSC(C[C@@H](C7=O)NC([C@H]%10[C@H]%11[C@@H]%10COC%11)=O)=N9)=C8)N5CC)=C([C@@H](OC)C)N=C4)CCC(C#N)CC3)C=C2)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (26.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5240 mL 2.6202 mL 5.2403 mL
5 mM 0.1048 mL 0.5240 mL 1.0481 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5240 mL 2.6202 mL 5.2403 mL 13.1008 mL
5 mM 0.1048 mL 0.5240 mL 1.0481 mL 2.6202 mL
10 mM 0.0524 mL 0.2620 mL 0.5240 mL 1.3101 mL
15 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.8734 mL
20 mM 0.0262 mL 0.1310 mL 0.2620 mL 0.6550 mL
25 mM 0.0210 mL 0.1048 mL 0.2096 mL 0.5240 mL
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Z56-L23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z56-L233077488-78-6Drug-Linker Conjugates for ADCRasAsPC-1 cellsNCI-H441 cellsEGFR antibodyHER3 antibodytumor cellsxenograft mouse modelscancerRAS proteinantibody-drug conjugatesEGFRxHER3 bispecific antibodyInhibitorinhibitorinhibit

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