3077488-78-6
Chemical Structure
Z56-L23
- CAS No.: 3077488-78-6
- Formula:C98H136N15O22S+
- Molecular Weight:1908.28
InChIKey: GWZNRIXDXBNILO-BOXCZQIPSA-O
SMILES: O=C([C@H](CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)NC(CCN1C(C=CC1=O)=O)=O)NCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC2=CC=C(C[N+]3(CC#CC4=C[C@]([C@]5=C(CC(C)(COC([C@H]6NN7CCC6)=O)C)C8=C(C=CC(C9=CSC(C[C@@H](C7=O)NC([C@H]%10[C@H]%11[C@@H]%10COC%11)=O)=N9)=C8)N5CC)=C([C@@H](OC)C)N=C4)CCC(C#N)CC3)C=C2)=O)=O)=O
Biological Activity: Z56-L23 is a conjugate of RAS-targeting ADC cytotoxic payload-linker with anti-tumor activity. Z56-L23 can be conjugated with HER3 antibody, EGFR antibody or EGFRxHER3 bispecific antibody to form intact antibody-drug conjugates (ADCs). ADC molecules related to Z56-L23 effectively inhibit the proliferation of tumor cells and also significantly suppress tumor growth in xenograft mouse models. Z56-L23 can be used in the research of pancreatic cancer[1].
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Z56-L23 | Z56-L23 is a conjugate of RAS-targeting ADC cytotoxic payload-linker with anti-tumor activity. Z56-L23 can be conjugated with HER3 antibody, EGFR antibody or EGFRxHER3 bispecific antibody to form intact antibody-drug conjugates (ADCs). ADC molecules related to Z56-L23 effectively inhibit the proliferation of tumor cells and also significantly suppress tumor growth in xenograft mouse models. Z56-L23 can be used in the research of pancreatic cancer. | |||||||||||||||||||||
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Keywords
