Coprelotamab
Based on 1 Customer Validation
Coprelotamab (GB-221) is a recombinant humanized IgG1-κ monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2/ERBB2). Coprelotamab can be used for research on HER2-positive breast cancer and gastric cancer.
For research use only. We do not sell to patients.
- CAS No.: 2348469-84-9
- Molecular Weight:145.34 kDa
-
Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
More
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
HER2 |
ErbB2 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
-
Immobilized HER2/CD340 Protein, Human (HEK293, HY-P73094) can bind Coprelotamab. The EC50 for this effect is 3.894 ng/mL. -
Flow cytometric analysis of 1×106 MCF-7 cells labelling HER2 (red) with Coprelotamab (HY-P99831). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
Chemical Information
-
CAS No. 2348469-84-9
-
Appearance Liquid
-
Molecular Weight 145.34 kDa
-
Color Colorless to light yellow
-
SMILES
[Coprelotamab]
-
Synonyms
GB-221
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (248 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)