Depatuxizumab
Based on 1 Customer Validation
Depatuxizumab is a brain-penetrant and humanized tumor-specific anti EGFR monoclonal antibody. Depatuxizumab inhibits the growth of xenograft models of mutant EGFRvIII and wild-type EGFR. Depatuxizumab can be used for research on cancer.
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 1471999-69-5
- Molecular Weight:144.54 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
Human IgG1 kappa
Human
ERBB1/EGFR/HER1
Depatuxizumab (10, 40 mg/kg, i.p., three times a week for 2 weeks) inhibits tumor growth and pEGFR levels in EGFRvIII-positive GBM SN0199 PDX models of NSG mice[1].
Depatuxizumab (2-40 mg/kg, i.p., three times a week for 2 weeks) inhibits tumor growth with dose dependent manner in SCC15 xenograft models of SCID Beige mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:U87MGde2-7 glioblastoma multiforme (GBM) model of Nu/Nu mice[1]
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Dosage:10, 40 mg/kg, three times a week for 2 weeks
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth significantly more than Cetuximab (HY-P9905).
Promoted a significant increase in TGI (tumor growth inhibition) when it combined with Temozolomide (HY-17364).
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Animal Model:EGFRvIII-positive GBM SN0199 PDX model, 3 to 5 mm3 passage 3 (P3) tumor fragments were s.c. trochar implanted in the right rear flank of NSG mice[1]
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Dosage:10, 40 mg/kg, three times a week for 2 weeks
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth significantly and reduced levels of pEGFR.
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Animal Model:A431 squamous xenograft model of Nu/Nu mice[1]
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Dosage:10, 40 mg/kg, three times a week for 2 weeks
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth with comparable activity to Cetuximab (HY-P9905) dosed in an equivalent manner at 10 mg/kg.
Inhibited tumor growth by 58% at 40 mg/kg.
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Animal Model:SCC15 xenograft model of SCID Beige mice[1]
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Dosage:2, 10, 20, 40 mg/kg, three times a week for 2 weeks
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth with dose manner.
Reduced the level of pEGFR and total EGFR in time-dependent.
Reduced cell proliferation as measured by phospho-histone H3.
Increased apoptosis as measured by caspase-3 cleavage.
Increased antitumor activity when it was combined with both Cisplatin(HY-17394) or/and 5-FU(HY-90006) at 10 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized EGFR Protein, Human can bind Depatuxizumab. The EC50 for this effect is 52.87 ng/mL. -
Flow Cytometry analysis of A431 cells labelling ERBB1/EGFR/HER1 (red) with Depatuxizumab (anti-ERBB1/EGFR/HER1) (HY-P99849). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1471999-69-5
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Appearance Liquid
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Molecular Weight 144.54 kDa
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Color Colorless to light yellow
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SMILES
[Depatuxizumab]
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Synonyms
ABT-806
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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