2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Depatuxizumab

Depatuxizumab  (Synonyms: ABT-806)

Cat. No.: HY-P99849 Purity: 99.58%
COA

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Depatuxizumab is a brain-penetrant and humanized tumor-specific anti EGFR monoclonal antibody. Depatuxizumab inhibits the growth of xenograft models of mutant EGFRvIII and wild-type EGFR. Depatuxizumab can be used for research on cancer.

For research use only. We do not sell to patients.

Depatuxizumab Chemical Structure

Depatuxizumab Chemical Structure

CAS No. : 1471999-69-5

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Description

Depatuxizumab is a brain-penetrant and humanized tumor-specific anti EGFR monoclonal antibody. Depatuxizumab inhibits the growth of xenograft models of mutant EGFRvIII and wild-type EGFR. Depatuxizumab can be used for research on cancer[1].

In Vivo

Depatuxizumab (10, 40 mg/kg, i.p., three times a week for 2 weeks) inhibits tumor growth significantly in U87MGde2-7 glioblastoma multiforme (GBM) models and A431 squamous xenograft models of Nu/Nu mice[1].
Depatuxizumab (10, 40 mg/kg, i.p., three times a week for 2 weeks) inhibits tumor growth and pEGFR levels in EGFRvIII-positive GBM SN0199 PDX models of NSG mice[1].
Depatuxizumab (2-40 mg/kg, i.p., three times a week for 2 weeks) inhibits tumor growth with dose dependent manner in SCC15 xenograft models of SCID Beige mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: U87MGde2-7 glioblastoma multiforme (GBM) model of Nu/Nu mice[1]
Dosage: 10, 40 mg/kg, three times a week for 2 weeks
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth significantly more than Cetuximab (HY-P9905).
Promoted a significant increase in TGI (tumor growth inhibition) when it combined with Temozolomide (HY-17364).
Animal Model: EGFRvIII-positive GBM SN0199 PDX model, 3 to 5 mm3 passage 3 (P3) tumor fragments were s.c. trochar implanted in the right rear flank of NSG mice[1]
Dosage: 10, 40 mg/kg, three times a week for 2 weeks
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth significantly and reduced levels of pEGFR.
Animal Model: A431 squamous xenograft model of Nu/Nu mice[1]
Dosage: 10, 40 mg/kg, three times a week for 2 weeks
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth with comparable activity to Cetuximab (HY-P9905) dosed in an equivalent manner at 10 mg/kg.
Inhibited tumor growth by 58% at 40 mg/kg.
Animal Model: SCC15 xenograft model of SCID Beige mice[1]
Dosage: 2, 10, 20, 40 mg/kg, three times a week for 2 weeks
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth with dose manner.
Reduced the level of pEGFR and total EGFR in time-dependent.
Reduced cell proliferation as measured by phospho-histone H3.
Increased apoptosis as measured by caspase-3 cleavage.
Increased antitumor activity when it was combined with both Cisplatin(HY-17394) or/and 5-FU(HY-90006) at 10 mg/kg.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Depatuxizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.58%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Depatuxizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Depatuxizumab1471999-69-5ABT-806ABT806ABT 806EGFREpidermal growth factor receptorErbB-1HER1U87MGde2-7A431SCC15permeation of blood-brain barrierxenograft modelPDX modelanticancerInhibitorinhibitorinhibit

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