2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Emibetuzumab

Emibetuzumab  (Synonyms: LY2875358)

Cat. No.: HY-P99192 Purity: 95.00%
COA

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Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer.

For research use only. We do not sell to patients.

Emibetuzumab Chemical Structure

Emibetuzumab Chemical Structure

CAS No. : 1365287-97-3

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5 mg USD 540 In-stock
10 mg USD 860 In-stock
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Based on 1 publication(s) in Google Scholar

Emibetuzumab Related Antibodies

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Description

Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer[1].

IC50 & Target

MET[1].
In Vitro

Emibetuzumab (LY2875358) (100 nmol/L; 6 days) inhibits HGF-stimulated proliferation of H596[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emibetuzumab Related Antibodies

Cell Proliferation Assay[1]

Cell Line: H596 cells (HGF-stimulated)
Concentration: 100 nmol/L
Incubation Time: 6 days
Result: Suppressed cell proliferation.
In Vivo

Emibetuzumab (LY2875358) (10 mg/kg; i.v.; once a week for 5 weeks) inhibits in vivo growth of glioblastoma U87MG xenograft tumors in mice[1].
Emibetuzumab (10 or 20 mg/kg; i.v.; single) downregulates levels of MET and pMET in the tumors of mice[1].
Emibetuzumab (10 mg/kg; i.v.; once a week for 3, 5 or 6 weeks) exhibits antitumor effects on MET-amplified xenograft mouse tumor models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (U87MG tumor xenograft model)[1].
Dosage: 10 mg/kg
Administration: Intravenous injection, once a week for 5 weeks.
Result: Demonstrated a significant inhibition of tumor growth.
Animal Model: Athymic nude mice (MKN45 xenograft tumor model)[1].
Dosage: 10 or 20 mg/kg
Administration: Intravenous injection, single.
Result: Reduced MET and pMET in the tumors by approximately 50% at both the 10 and 20 mg/kg doses by 72 hours post dose, and the reductions persisted to 14 days.
Animal Model: Athymic nude mice (MET-amplified xenograft mouse tumor models)[1].
Dosage: 10 mg/kg
Administration: Intravenous injection, once a week for 3, 5 or 6 weeks.
Result: Resulted in a marked reduction in tumor growth in the MKN45/SNU-5/EBC-1 gastric xenograft tumors.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Emibetuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Emibetuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emibetuzumab1365287-97-3LY2875358LY 2875358LY-2875358c-Met/HGFRcancerH596tumorMKN45SNU-5EBC-1Inhibitorinhibitorinhibit

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