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Cat. No.: HY-P991968

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HTI-1511 Antibody

(Synonyms: Halozyme patent anti-EGFR)

HTI-1511 Antibody (Halozyme patent anti-EGFR) is a monoclonal antibody inhibitor targeting EGFR. HTI-1511 Antibody can be used to synthesize a novel anti-EGFR-ADC, HTI-1511. HTI-1511 Antibody can be used in the research of head and neck squamous cell carcinoma, non-small cell lung cancer, pancreatic cancer, colorectal cancer, renal cell carcinoma, and epidermoid carcinoma.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HTI-1511 Antibody Chemical Structure

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Species Reactivity

Human

All EGFR Isoforms :

In Vitro

HTI-1511 potently inhibits the growth of SCC15, CAL27, FaDu, CAL33, SCC25, HCC827, NCI-H1666, PC-9, NCI-H1650, BxPC-3, PANC-1, and AsPC-1 cell lines in vitro with IC₅₀ values ranging from 0.04 nM to 6.2 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HTI-1511 Antibody (3.0 mg/kg; weekly; up to 8 weeks) delivers 93% tumor growth inhibition in human A431 epidermoid carcinoma xenografts, with no observed toxicity^[1].
HTI-1511 Antibody (3.0 mg/kg; weekly; up to 8 weeks) achieves greater than 100% tumor growth inhibition in human BxPC3 pancreatic carcinoma xenografts, with no observed toxicity^[1].
HTI-1511 Antibody (3.0 mg/kg; weekly; up to 8 weeks) achieves greater than 100% tumor growth inhibition in human AsPC-1 pancreatic carcinoma xenografts, with no observed toxicity^[1].
HTI-1511 Antibody (1.0-3.0 mg/kg; weekly) achieves greater than 100% tumor growth inhibition in KRAS-mutant non-small cell lung cancer patient-derived xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

1956 [NCBI]

Accession

P00533

Target

ERBB1/EGFR/HER1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[HTI-1511 Antibody]
Synonyms

Halozyme patent anti-EGFR
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Jesse D. Bahn, et al. Abstract 50: HTI-1511, a novel anti-EGFR-ADC, overcomes mutation resistance and demonstrates significant activity against multiple tumor types in preclinical studies. Cancer Res (2017) 77 (13_Supplement): 50.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

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MCE Japan Authorized Agent:

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HTI-1511 Antibody

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HTI-1511 Antibody Related Classifications

HY-P991968 Related Classifications