2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. HTI-1511 Antibody

HTI-1511 Antibody  (Synonyms: Halozyme patent anti-EGFR)

Cat. No.: HY-P991968
Technical Support

HTI-1511 Antibody is a monoclonal antibody inhibitor targeting EGFR. HTI-1511 Antibody can be used to synthesize a novel anti-EGFR-ADC, HTI-1511. HTI-1511 Antibody can be used in the research of head and neck squamous cell carcinoma, non-small cell lung cancer, pancreatic cancer, colorectal cancer, renal cell carcinoma, and epidermoid carcinoma.

For research use only. We do not sell to patients.

HTI-1511 Antibody

HTI-1511 Antibody Chemical Structure

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HTI-1511 Antibody Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

HTI-1511 Antibody is a monoclonal antibody inhibitor targeting EGFR. HTI-1511 Antibody can be used to synthesize a novel anti-EGFR-ADC, HTI-1511. HTI-1511 Antibody can be used in the research of head and neck squamous cell carcinoma, non-small cell lung cancer, pancreatic cancer, colorectal cancer, renal cell carcinoma, and epidermoid carcinoma[1].

Species Reactivity

Human
In Vitro

HTI-1511 potently inhibits the growth of SCC15, CAL27, FaDu, CAL33, SCC25, HCC827, NCI-H1666, PC-9, NCI-H1650, BxPC-3, PANC-1, and AsPC-1 cell lines in vitro with IC50 values ranging from 0.04 nM to 6.2 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HTI-1511 Antibody Related Antibodies
In Vivo

HTI-1511 Antibody (3.0 mg/kg; weekly; up to 8 weeks) delivers 93% tumor growth inhibition in human A431 epidermoid carcinoma xenografts, with no observed toxicity[1].
HTI-1511 Antibody (3.0 mg/kg; weekly; up to 8 weeks) achieves greater than 100% tumor growth inhibition in human BxPC3 pancreatic carcinoma xenografts, with no observed toxicity[1].
HTI-1511 Antibody (3.0 mg/kg; weekly; up to 8 weeks) achieves greater than 100% tumor growth inhibition in human AsPC-1 pancreatic carcinoma xenografts, with no observed toxicity[1].
HTI-1511 Antibody (1.0-3.0 mg/kg; weekly) achieves greater than 100% tumor growth inhibition in KRAS-mutant non-small cell lung cancer patient-derived xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID

1956  [NCBI]

Accession
Target

ERBB1/EGFR/HER1
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[HTI-1511 Antibody]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HTI-1511 Antibody Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HTI-1511 AntibodyHalozyme patent anti-EGFREGFREpidermal growth factor receptorErbB-1HER1head and neck squamous cell carcinomaepidermoid carcinomatumor microenvironmentsolid tumor cellsnon-small cell lung cancerpancreatic carcinomaMMAEcolorectal cancerrenal cell carcinomaInhibitorinhibitorinhibit

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