2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Futuximab

Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity.

For research use only. We do not sell to patients.

Futuximab Chemical Structure

Futuximab Chemical Structure

CAS No. : 1310460-85-5

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Futuximab Related Antibodies

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Description

Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity[1].

In Vitro

Futuximab (20 µg/mL; 24-48 h) induces EGFR variant III (EGFRvIII) internalization and slightly reduces EGFRvIII levels in NR6M cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Futuximab Related Antibodies

Western Blot Analysis[1]

Cell Line: NR6M cells
Concentration: 20 µg/mL
Incubation Time: 24 h or 48 h
Result: Slightly reduced EGFRvIII levels in NR6M cells.
In Vivo

Futuximab (50 mg/kg; i.p.; twice weekly; for 5 weeks) shows anti-tumor activity in EGFRwt expressing xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nu/nu mice injected with EGFRwt (D08-0308MG) patient-derived glioblastoma xenografts (PDX)[1]
Dosage: 50 mg/kg
Administration: i.p.; twice weekly; for 5 weeks
Result: Inhibited tumor growth in EGFRwt expressing xenograft model.
Clinical Trial
CAS No.
SMILES

[Futuximab]
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Futuximab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Futuximab1310460-85-5EGFREpidermal growth factor receptorErbB-1HER1chimeric monoclonal antibodyantineoplastic activityEGFRvIIIInhibitorinhibitorinhibit

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