ST8155AA1
ST8155AA1 is a part of antibody agent conjugates (ADCs) charged with HDAC inhibitor. ST8155AA1 induces α-tubulin, histone H3/H4 acetylation via direct enzymatic inhibition. ST8155AA1 recognizes and binds EGFR, undergoes internalization into EGFR-expressing tumor cells. ST8155AA1 inhibits cancer cell proliferation and exerts activity in mouse tumor models. ST8155AA1 can be used for the research of non-small cell lung cancer.
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- CAS 番号: 2247025-63-2
- 分子式: C43H62N8O9S
- 分子量:867.07
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Traditional Cytotoxic Agents |
ST8155AA1 specifically binds to EGFR with sub-nanomolar range affinity[1].
ST8155AA1 is efficiently internalized into EGFR-expressing Capan-1, NCI-H1975, and A549 human tumor cells following target binding[1].
ST8155AA1 inhibits HDAC activity in NCI-H1975 human lung carcinoma cells, as evidenced by increased acetylation of alpha-tubulin and histones H3 and H4[1].
ST8155AA1 (6 days) inhibits proliferation of NCI-H1975 and Calu-3 human lung adenocarcinoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude Nu/Nu mice subcutaneously injected with NCI-H1975 cells[1]
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Dosage:50 mg/kg
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Administration:i.p.; once every 4 days; 4 doses
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Result:Exhibited anti-tumor activity.
Showed no change in body weight.
化学情報
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CAS 番号 2247025-63-2
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分子量 867.07
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分子式 C43H62N8O9S
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SMILES
O=C(O)CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CSCCCCC[C@H](NC([C@H]2CCC(N2)=O)=O)C(NC3=CC=CC=C3)=O)C=C1)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ST8155AA1 関連分類
HY-112806 関連分類
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