2247025-63-2
Chemical Structure
ST8155AA1
- CAS. Nr.: 2247025-63-2
- Formula:C43H62N8O9S
- Molecular Weight:867.07
IUPAC Name: 7-(((S)-3-methyl-1-oxo-1-(((S)-1-oxo-1-((4-((((S)-7-oxo-6-((R)-5-oxopyrrolidine-2-carboxamido)-7-(phenylamino)heptyl)thio)methyl)phenyl)amino)-5-ureidopentan-2-yl)amino)butan-2-yl)amino)-7-oxoheptanoic acid
InChIKey: GAYBMHZYLPNGIW-XGHZCBFSSA-N
SMILES: O=C(O)CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CSCCCCC[C@H](NC([C@H]2CCC(N2)=O)=O)C(NC3=CC=CC=C3)=O)C=C1)=O)=O)=O
Biological Activity: ST8155AA1 is a part of antibody agent conjugates (ADCs) charged with HDAC inhibitor. ST8155AA1 induces α-tubulin, histone H3/H4 acetylation via direct enzymatic inhibition. ST8155AA1 recognizes and binds EGFR, undergoes internalization into EGFR-expressing tumor cells. ST8155AA1 inhibits cancer cell proliferation and exerts activity in mouse tumor models. ST8155AA1 can be used for the research of non-small cell lung cancer[1].
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ST8155AA1 | ST8155AA1 is a part of antibody agent conjugates (ADCs) charged with HDAC inhibitor. ST8155AA1 induces α-tubulin, histone H3/H4 acetylation via direct enzymatic inhibition. ST8155AA1 recognizes and binds EGFR, undergoes internalization into EGFR-expressing tumor cells. ST8155AA1 inhibits cancer cell proliferation and exerts activity in mouse tumor models. ST8155AA1 can be used for the research of non-small cell lung cancer. | |||||||||||||||||||||
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