86 Results for "

Platelet membrane

" in MedChemExpress (MCE) Product Catalog:
Products (86)

86 Results for "Platelet membrane" in MCE Product Catalog:

10
10 Publications Verification
Cat. No.: HY-N0570
CAS No.: 10597-60-1
Synonyms: DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol
Hydroxytyrosol (DOPET; 3,4-Dihydroxyphenethyl alcohol) is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
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3
3 Cited Publications
Cat. No.: HY-P0074
CAS No.: 67869-62-9
Synonyms: Gly-Pro-Arg-Pro; Pefa 6003
Target:  

Thrombin

Research Areas:  

Cardiovascular Disease

GPRP (Gly-Pro-Arg-Pro; Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction between fibrinogen and the platelet membrane glycoprotein Ⅱb/IIIa complex (glycoprotein IIb/IIIa receptor) . GPRP increases the level of free thrombin in activated platelet-rich plasma by reducing the adsorption of thrombin onto fibrin. GPRP inhibits platelet aggregation and prolongs the thrombin-initiated clotting time in plasma. GPRP is applicable for research related to thrombosis and thrombotic diseases .
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3
3 Cited Publications
Cat. No.: HY-P0074A
CAS No.: 157009-81-9
Synonyms: Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate
Target:  

Integrin

Research Areas:  

Cardiovascular Disease

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .
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2
2 Cited Publications
Cat. No.: HY-100957
CAS No.: 20153-98-4
Purity:  99.64%
Research Areas:  

Cardiovascular Disease

Dilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides .
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2
2 Cited Publications
Cat. No.: HY-108355
CAS No.: 120166-69-0
Purity:  ≥98.0%
Target:  

PKC

Research Areas:  

Cancer

R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol .
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1
1 Cited Publications
Cat. No.: HY-B0590
CAS No.: 58-46-8
Synonyms: Ro 1-9569
Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 Ki 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .
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1
1 Cited Publications
Cat. No.: HY-P70803
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELP; Selectin P (Granule membrane Protein 140kDa, Antigen CD62); Prev. GRMP; LECAM3; P-Selectin; Selectin P (Granule membrane Protein 140kD, Antigen CD62); PADGEM; Leukocyte-Endothelial Cell Adhesion Molecule 2; Platelet Activation Dependent Granule-Exte
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P700752
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGA2; Alpha 2 Integrin; Prev. CD49B; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; GPIa; Very Late Activation Receptor Alpha-2 Subunit; CD49 Antigen-Like Family Member B; Human Platelet Alloantigen System 5; Platelet membrane Glycoprotein Ia
Species:  
Source:  
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Cat. No.: HY-B0590S
CAS No.: 1392826-25-3
Synonyms: Ro 1-9569-d6
Tetrabenazine-d6 (Deutetrabenazine) is a deuterium-labled Tetrabenazine (HY-B0590). Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 Ki 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .
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Cat. No.: HY-W089800
CAS No.: 18829-56-6
Synonyms: trans-2-Nonen-1-al
Category:  

Natural Products

Target:  

COX Lipoxygenase Apoptosis

trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .
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Cat. No.: HY-N6043
CAS No.: 69039-02-7
Hydroxytyrosol acetate is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol acetate not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol acetate effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol acetate significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol acetate has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
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Cat. No.: HY-107867
CAS No.: 135046-48-9
Purity:  99.39%
(±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .
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Cat. No.: HY-W337335
CAS No.: 17618-08-5
Synonyms: 1-P-GPA sodium salt
Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) sodium salt is a type of phospholipid and a precursor of lipid membranes. 1-Palmitoyl-sn-glycerol 3-phosphate sodium salt can be incorporated into POPC liposomes, resulting in significant changes in membrane curvature. 1-Palmitoyl-sn-glycerol 3-phosphate sodium salt can induce platelet aggregation, but its activity is 30 times lower than that of 1-hexadecyl-sn-glyceryl-3-phosphate .
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Cat. No.: HY-B0590A
CAS No.: 718635-93-9
Synonyms: Ro 1-9569 Racemate
Tetrabenazine (Ro 1-9569) Racemate is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 Ki 100 nM. Tetrabenazine Racemate binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine Racemate weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine Racemate can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .
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Cat. No.: HY-P3012
CAS No.: 107200-92-0
Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases .
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Cat. No.: HY-125139
CAS No.: 123940-93-2
Purity:  ≥98.0%
Synonyms: ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%
omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
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Cat. No.: HY-N0570R
CAS No.: 10597-60-1
Synonyms: DOPET (Standard); 3,4-Dihydroxyphenethyl alcohol (Standard); 3-Hydroxytyrosol (Standard)
Hydroxytyrosol (Standard) (DOPET (Standard)) is the analytical standard of Hydroxytyrosol (HY-N0570). This product is intended for research and analytical applications. Hydroxytyrosol is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
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Cat. No.: HY-141581
CAS No.: 74430-89-0
Purity:  ≥98.0%
Lyso-PAF C-18 is a single-chain ether phospholipid with membrane regulatory activity, and Lyso-PAF is the deacetylated inactive precursor of PAF. Lyso-PAF C-18 regulates the activity of plasma membrane Ca 2+-ATPase, and its mechanism of action may involve altering the lipid microenvironment of this enzyme. Lyso-PAF C-18 activates the calcium ATPase in rat synaptosomal membranes and inhibits the calcium ATPase in rat leukocyte membranes. Lyso-PAF C-18 can be used in cell membrane-related research .
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Cat. No.: HY-158741
CAS No.: 1369302-24-8
Synonyms: APG-2 Acetoxymethyl ester
IPG-2 AM (APG-2 Acetoxymethyl ester) is a membrane-permeant acetoxymethyl ester derivative and selective fluorescent potassium ion indicator. IPG-2 AM exhibits fluorescence increases proportional to extracellular potassium ion concentrations. IPG-2 AM enables real-time monitoring of cytosolic free potassium ion fluxes in human platelets and macrophages. IPG-2 AM can be used for the research of intracellular potassium concentration dynamics .
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Cat. No.: HY-126967A
CAS No.: 7220-34-0
Purity:  ≥99.0%
Synonyms: 1-P-GPA
1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) is a phospholipid and lipid membrane precursor. 1-Palmitoyl-sn-glycerol 3-phosphate integrates into POPC liposomes, causing significant changes in membrane curvature. 1-Palmitoyl-sn-glycerol 3-phosphate induces platelet aggregation, but its activity is 30-fold lower than that of 1-hexadecyl-sn-glyceryl-3-phosphate .
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