Copy Link Print Information

CD41 Antibody (YA1839)

(Synonyms: ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41)
Customer Review

Based on 1 Customer Validation

CD41 Antibody (YA1839) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD41.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for CD41 Antibody (YA1839)
  • CD41 Antibody (YA1839) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download
Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-1:2000 1:1000

Product Details

Description

CD41 Antibody (YA1839) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD41.

  • Host Rabbit
  • Clonality Monoclonal,Recombinant
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 113-140 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 113 kDa
Species Reactivity Database
Immunogen

Recombinant protein within mouse CD41 aa 451-989.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3104210

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for CD41 Antibody (YA1839)
    Western blot analysis of extracts from C6 (lane 2, 20ug), Hela (lane 3, 20ug), Rat lung (lane 4, 20ug) and Mouse lung (lane 5, 20ug) using CD41 Antibody (HY-P82094). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST for 2 hour at room temperature. Goat Anti-Rabbit IgG-HRP Secondary Antibody (HY-P8001, 1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    CD41 (Integrin αIIb, GPIIb) is an integrin α subunit encoded by the ITGA2B gene. Together with CD61 (Integrin β3), it forms αIIbβ3 integrin (GPIIb/IIIa), which is a crucial receptor in platelet aggregation and hemostasis. CD41 is mainly expressed in platelets and megakaryocytes, mediating platelet aggregation and stabilizing thrombus formation by binding ligands such as fibrinogen and vWF. CD41 is not only a classic biomarker for platelets and megakaryocytes, but also an important target for immunophenotyping of acute megakaryocytic leukemia (AML-M7), hematopoietic development research, and the development of antiplatelet drugs.

  • Subcellular Localization

    Membrane; Single-pass type I membrane protein

  • Expression


    Tissue_specificity:Isomers 1 and 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. They were not detected in Jurkat cells or the U937 cell line (PubMed: 2351656) . Isomer 3 is expressed in prostate adenocarcinoma and various erythroleukemia, prostate adenocarcinoma, and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B, and WM35. It was not detected in platelets or normal prostate tissue (protein level) (PubMed: 9809974) .

  • Isoforms & Post-Translational Modification

    CD41 has 3 isomers: P08514-1: 113377 Da (predicted); P08514-2: 109574 Da (predicted); P08514-3: 103218 Da (predicted).
    Cleaved by ELANE; the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3

  • Subunit

    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond.

  • SwissProt ID

    P08514

  • Gene ID
    3674 [NCBI]
  • Synonyms

    ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41

  • Research Field

    Cardiovascular

CD41 Antibody (YA1839) Related Classifications

MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from C6 (lane 2, 20ug), Hela (lane 3, 20ug), Rat lung (lane 4, 20ug) and Mouse lung (lane 5, 20ug) using CD41 Antibody (HY-P82094). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST for 2 hour at room temperature. Goat Anti-Rabbit IgG-HRP Secondary Antibody (HY-P8001, 1/10,000) was used for 1 hour at room temperature.

  • CD41 Antibody (YA1839) Product Image
    1/16
  • Experimental Validation Results for CD41 Antibody (YA1839)
  • CD41 Antibody (YA1839) Product Image
  • Experimental Validation Results for CD41 Antibody (YA1839)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from C6 (lane 2, 20ug), Hela (lane 3, 20ug), Rat lung (lane 4, 20ug) and Mouse lung (lane 5, 20ug) using CD41 Antibody (HY-P82094). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST for 2 hour at room temperature. Goat Anti-Rabbit IgG-HRP Secondary Antibody (HY-P8001, 1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for CD41 Antibody (YA1839)
  • CD41 Antibody (YA1839) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from C6 (lane 2, 20ug), Hela (lane 3, 20ug), Rat lung (lane 4, 20ug) and Mouse lung (lane 5, 20ug) using CD41 Antibody (HY-P82094). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST for 2 hour at room temperature. Goat Anti-Rabbit IgG-HRP Secondary Antibody (HY-P8001, 1/10,000) was used for 1 hour at room temperature.

  • CD41 Antibody (YA1839) Product Image WB