Dilazep
Based on 2 publication(s) in Google Scholar
Dilazep is an inhibitor of adenosine uptake. Dilazep has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 35898-87-4
- 分子式: C31H44N2O10
- 分子量:604.69
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
MedChemExpress(MCE)の使用を引用している文献 Dilazep
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Cell Imaging/Staining
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9c2 | IC50 |
8800 nM
Compound: DZ
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Inhibition of rat ENT2 expressed in rat H9c2 cells by cell-based 3H[5-]uridine uptake assay
Inhibition of rat ENT2 expressed in rat H9c2 cells by cell-based 3H[5-]uridine uptake assay
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[PMID: 25454272] |
| HEK293 | IC50 |
>50 μM
Compound: Dilazep
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TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP5-expressing HEK293 cells
TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP5-expressing HEK293 cells
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[PMID: 12695538] |
| HEK293 | IC50 |
20 μM
Compound: Dilazep
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TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP4-expressing HEK293 cells
TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP4-expressing HEK293 cells
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[PMID: 12695538] |
| U2OS | IC50 |
0.1 nM
Compound: 3074
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Inhibition of the equilibrative nucleoside transporter (ENT1, SLC29A1) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay (PubChem AID: 1745861)
Inhibition of the equilibrative nucleoside transporter (ENT1, SLC29A1) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay (PubChem AID: 1745861)
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[PMID: 31551431] |
化学情報
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CAS 番号 35898-87-4
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分子量 604.69
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分子式 C31H44N2O10
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SMILES
O=C(C1=CC(OC)=C(OC)C(OC)=C1)OCCCN2CCN(CCCOC(C3=CC(OC)=C(OC)C(OC)=C3)=O)CCC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Dilazep purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 23.
Cell numbers were measured using the CyQUANT assay after 12 days culture in glutamine-deprived medium supplemented with 1 mM α-KG and 2.5 µM exDNA, with or without co-treatment using nucleoside transporter inhibitors (NBTI, DPL, or Dilazep dihydrochloride) at 0.01 µM (+), 0.1 µM (++), or 1 µM (+++).
Dilazep purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 23.
Cell numbers were measured using the CyQUANT assay after 12 days culture in glutamine-deprived medium supplemented with 1 mM α-KG and 2.5 µM exDNA, with or without co-treatment using nucleoside transporter inhibitors (NBTI, DPL, or Dilazep dihydrochloride) at 0.01 µM (+), 0.1 µM (++), or 1 µM (+++).
Dilazep purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 23.
Cell numbers were measured using the CyQUANT assay after 12 days culture in glutamine-deprived medium supplemented with 1 mM α-KG and 2.5 µM exDNA, with or without co-treatment using nucleoside transporter inhibitors (NBTI, DPL, or Dilazep dihydrochloride) at 0.01 µM (+), 0.1 µM (++), or 1 µM (+++).
Dilazep purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 23.
Cell numbers were measured using the CyQUANT assay after 12 days culture in glutamine-deprived medium supplemented with 1 mM α-KG and 2.5 µM exDNA, with or without co-treatment using nucleoside transporter inhibitors (NBTI, DPL, or Dilazep dihydrochloride) at 0.01 µM (+), 0.1 µM (++), or 1 µM (+++).
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Dilazep purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 4.
Representative images of WT Hela cells or VPS13B KO cells treated with: azelastine (AZL); Dilazep dihydrochloride (DLZ). 10 µM, 24 h. cells were fixed and stained with an anti-LBPA antibody (upper panel) of with Filipin (lower panel).
純度とドキュメンテーション
参考文献
[1]. Zhang Y, et al. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation. J Pharmacol Exp Ther. 1991 Sep;258(3):767-71. [Content Brief]
[2]. Kawagoe J, et al. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):485-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)