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Cat. No.: HY-P86724A

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CD41 Antibody (YA6416)(PBS only)

(Synonyms: platelet glycoprotein IIb of IIb/IIIa complex; Integrin, alpha 2b(platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GPIIb; GTA; HPA3; CD 41; CD41 antigen; CD41a; CD41b; GP2b; GPalpha IIb; GPalphaIIb; Integrin alpha IIb; Integrin alpha IIb precursor; ITGA 2B; Integrin alpha 2b; ITGAB; Platelet fibrinogen receptor alpha; Platelet fibrinogen receptor alpha subunit; Platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; Platelet specific antigen bak; ITA2B_HUMAN.)

CD41 Antibody (YA6416) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD41.

For research use only. We do not sell to patients.

Host:
Mouse
Isotype:
IgG1
Application:
WB, FC
Reactivity :
Human

Formulation:
Supplied in PBS, pH 7.4.

Conjugation:
Non-conjugated

Size

Price

Stock

Quantity

Sample (0.1mg)

In-stock

(In Japan)

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Bioz

Applications

Application	WB WB: Western Blot	FC FC: Flow Cytometry
Dilution Ratio	1:500-2000	1ug:Test

Product Details

Description

CD41 Antibody (YA6416) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD41.

Host Mouse
Species Reactivity
Human
Calculated Molecular Weight Predicted band size: 125 kDa

Immunogen

KLH conjugated synthetic peptide derived from human ITGA2B

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity)
Subcellular Localization

Membrane
Expression

Tissue_Specificity: Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974)
Isoforms & Post-Translational Modification

P08514 has three isomers: P08514-1: 113377 Da (predicted); P08514-2: 109574 Da (predicted); P08514-3: 103218 Da (predicted).
Cleaved by ELANE; the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3
Subunit

Heterodimer of an alpha and a beta subunit
SwissProt ID

P08514
Gene ID

3674 [NCBI]
Synonyms

platelet glycoprotein IIb of IIb/IIIa complex; Integrin, alpha 2b(platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GPIIb; GTA; HPA3; CD 41; CD41 antigen; CD41a; CD41b; GP2b; GPalpha IIb; GPalphaIIb; Integrin alpha IIb; Integrin alpha IIb precursor; ITGA 2B; Integrin alpha 2b; ITGAB; Platelet fibrinogen receptor alpha; Platelet fibrinogen receptor alpha subunit; Platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; Platelet specific antigen bak; ITA2B_HUMAN.