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Referencia número: HY-P85675

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CD41 Antibody (YA5367)

(Synonyms: ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41)

CD41 Antibody (YA5367) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD41.

For research use only. We do not sell to patients.

Host:
Mouse
Application:
IHC-P, ICC/IF
Reactivity :
Human

Formulation:
Supplied in PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Conjugation:
Non-conjugated

Tamaño

Precio

Stock

Cantidad

Sample (0.1mg)

In-stock

(In Japan)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Envío
Background
Documentación
Help & FAQs
Bioz

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:100	1:50-200

Product Details

Descripciòn

CD41 Antibody (YA5367) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD41.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human
Calculated Molecular Weight Predicted band size: 113 kDa

Immunogen

Synthetic Peptide of CD41

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Product Properties

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.

Background

Function

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity)
Subcellular Localization

Membrane; Single-pass type I membrane protein
Expression

Tissue_specificity:Isomers 1 and 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. They were not detected in Jurkat cells or the U937 cell line (PubMed: 2351656) . Isomer 3 is expressed in prostate adenocarcinoma and various erythroleukemia, prostate adenocarcinoma, and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B, and WM35. It was not detected in platelets or normal prostate tissue (protein level) (PubMed: 9809974) .
Isoforms & Post-Translational Modification

P08514 has 3 isomers: P08514-1: 113377 Da (predicted); P08514-2: 109574 Da (predicted); P08514-3: 103218 Da (predicted).
Cleaved by ELANE; the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3
Subunit

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond.
SwissProt ID

P08514
Gene ID

3674 [NCBI]
Synonyms

ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41