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    TGF-beta/Smad
  2. PKC
  3. R59949

R59949 

Cat. No.: HY-108355 Purity: ≥98.0%
Handling Instructions

R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol.

For research use only. We do not sell to patients.

R59949 Chemical Structure

R59949 Chemical Structure

CAS No. : 120166-69-0

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5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol[1][2][3].

In Vitro

In the presence of R59949, vasopressin- as well as collagen-induced release reaction and aggregation was strongly increased, independently of the formation of arachidonate metabolites[1].
In THP‐1 monocytes, R59949 attenuates CCL2‐evoked Ca2+ signalling with a half‐maximal concentration of 8.6 μM[2].
R59949 inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

489.58

Formula

C₂₈H₂₅F₂N₃OS

CAS No.

120166-69-0

SMILES

O=C1N(CCN2CC/C(CC2)=C(C3=CC=C(F)C=C3)\C4=CC=C(F)C=C4)C(NC5=C1C=CC=C5)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: ≥98.0%

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Keywords:

R59949R 59949R-59949PKCProtein kinase CdiacylglycerolkinaseendogenousligandplateletplasmamembranesInhibitorinhibitorinhibit

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R59949
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