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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13447A
    PF429242 dihydrochloride
    Maximum Cited Publications
    10 Publications Verification

    		 Fatty Acid Synthase (FASN) Virus Protease Infection Metabolic Disease
    PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM .
    PF429242 dihydrochloride
  • HY-135136
    Aldehyde reactive probe TFA

    		Biochemical Assay Reagents Fluorescent Dye Others
    Aldehyde reactive probe TFA is an aldehyde reactive probe. Aldehyde reactive probe TFA specifically labels the AP site in DNA with biotin residues. Aldehyde reactive probe TFA can detect RNA oxidation-induced debasement sites. Aldehyde reactive probe TFA can be used to quantify AP sites or detect other aldehyde-containing DNA damage and RNA oxidation-induced debasement sites .
    Aldehyde reactive probe TFA
  • HY-15419
    RS-127445 hydrochloride
    3 Publications Verification

    		 5-HT Receptor Neurological Disease
    RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites .
    RS-127445 hydrochloride
  • HY-15688
    8-OH-DPAT hydrobromide
    5+ Cited Publications

    8-Hydroxy-DPAT hydrobromide

    		 5-HT Receptor Neurological Disease Metabolic Disease
    8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent, brain-penetrant and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site .
    8-OH-DPAT hydrobromide
  • HY-112041
    Unesbulin
    3 Publications Verification

    PTC596

    		 BMI1 Apoptosis Cancer
    Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .
    Unesbulin
  • HY-13509
    CCG-50014
    2 Publications Verification

    		 RGS Protein Inflammation/Immunology
    CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test .
    CCG-50014
  • HY-13447
    PF-429242
    Maximum Cited Publications
    10 Publications Verification

    		 Fatty Acid Synthase (FASN) Virus Protease Infection Metabolic Disease
    PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM .
    PF-429242
  • HY-P3208B
    Endoproteinase Lys-C (MS grade)

    		Biochemical Assay Reagents Others
    Endoproteinase Lys-C (MS grade) is a hydrolase that cleaves peptide bonds at the carboxyl side of lysine residues. Endoproteinase Lys-C (MS grade) causes non-specific hydrolysis of peptide bonds linked to the carboxyl groups of non-lysine residues, resulting in partial cleavage at these sites .
    Endoproteinase Lys-C (MS grade)
  • HY-P3005
    T4 DNA ligase

    		DNA/RNA Synthesis Others
    T4 DNA ligase is the product of gene 30 of phage T4. T4 DNA ligase catalyzes the repair of single-stranded nicks in duplex DNA and joins duplex DNA restriction fragments having either blunt or cohesive ends. T4 DNA ligase catalyze the sealing of adjacent 5′-phosphate and 3′-­hydroxyl termini at single-stranded breaks in double-stranded DNA.T4 DNA ligase is an ATP-dependent ligase enzyme. T4 DNA ligase can be used in various biotechnological applications. T4 DNA ligase can join the ends of single-stranded DNA in the absence of any duplex DNA structure at the ligation site .
    T4 DNA ligase
  • HY-134636
    PAPA NONOate
    2 Publications Verification

    		 Endogenous Metabolite Endocrinology
    PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site .
    PAPA NONOate
  • HY-12429
    Beclabuvir
    5 Publications Verification

    BMS-791325

    		 DNA/RNA Synthesis HCV Infection
    Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM .
    Beclabuvir
  • HY-101382
    GR 103691
    2 Publications Verification

    		 Dopamine Receptor Neurological Disease
    GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites .
    GR 103691
  • HY-15419A
    RS-127445
    3 Publications Verification

    		 5-HT Receptor Neurological Disease
    RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites .
    RS-127445
  • HY-19151
    Fuzapladib

    IS-741

    		 Integrin Phospholipase Inflammation/Immunology
    Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .
    Fuzapladib
  • HY-D0871
    CHES

    N-Cyclohexyltaurine

    		 Biochemical Assay Reagents Influenza Virus Infection
    CHES (N-Cyclohexyltaurine) is a biological buffer reagent that binds to influenza virus hemagglutinin (HA). CHES mimics the binding mode of sialic acid to the HA receptor-binding site .
    CHES
  • HY-P1826
    CLIP (86-100)

    		CD74 Inflammation/Immunology Cancer
    CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site .
    CLIP (86-100)
  • HY-110160
    Pozanicline dihydrochloride

    ABT-089 dihydrochloride

    		 nAChR Neurological Disease
    Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [ 3H]cytisine sites . Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant .
    Pozanicline dihydrochloride
  • HY-132870
    MEIS-IN-2

    		HOXA Others
    MEIS-IN-2 is a myeloid ecotropic viral integration site 1 (MEIS1) inhibitor.
    MEIS-IN-2
  • HY-163097
    ZCAN262

    		iGluR Neurological Disease
    ZCAN262 (compound 6 ) is an AMPA modulator. ZCAN262 prevents AMPA-mediated excitotoxicity by targeting an allosteric binding site .
    ZCAN262
  • HY-19151A
    Fuzapladib sodium

    IS-741 sodium

    		 Integrin Phospholipase Inflammation/Immunology
    Fuzapladib (IS-741) sodium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib sodium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib sodium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .
    Fuzapladib sodium
  • HY-110087
    4BP-TQS

    		nAChR Neurological Disease
    4BP-TQS is a potent allosteric agonist of α7 nAChR. 4BP-TQS activates nAChRs via an allosteric transmembrane site .
    4BP-TQS
  • HY-19168
    Perzinfotel

    EAA-090

    		 iGluR Neurological Disease
    Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity (IC50=30 nM) for the glutamate site .
    Perzinfotel
  • HY-115749
    D-Luciferin 6′-methyl ether

    6′-Methoxyluciferin

    		 Fluorescent Dye Others
    D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 µM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site .
    D-Luciferin 6′-methyl ether
  • HY-15419R
    RS-127445 hydrochloride (Standard)

    		5-HT Receptor Neurological Disease
    RS-127445 (hydrochloride) (Standard) is the analytical standard of RS-127445 (hydrochloride). This product is intended for research and analytical applications. RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites .
    RS-127445 hydrochloride (Standard)
  • HY-P3605
    GnRH Associated Peptide (25-53), human

    GAP (25-53), human

    		 GnRH Receptor Endocrinology
    GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .
    GnRH Associated Peptide (25-53), human
  • HY-P11406
    Ac-RSLK-AMC

    		Fluorescent Dye Others
    Ac-RSLK-AMC is a fluorogenic substrate, can be used to measure the enzymatic activities of site-1 protease (S1P) .
    Ac-RSLK-AMC
  • HY-172545
    AMG28

    		Tau Protein Neurological Disease
    AMG28 is an ATP-competitive inhibitor targeting TTBK1 and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. AMG28 inhibits the phosphorylation of tau protein at the Ser422 site .
    AMG28
  • HY-115527
    SHP244

    		SHP2 Cancer
    SHP244 is a conformational inhibitor targeting the "latch allosteric site" (site 2) of the SHP2 protein with an IC50 value for SHP2 WT of 60 μM. SHP244 has no significant effect on the level of p-ERK alone. SHP244 combined with RMC-4550 (HY-116009) ("tunnel site" site 1 inhibitor) can reduce p-ERK and inhibit the rebound of p-ERK, thereby reducing drug resistance. SHP244 can be used to study drug resistance in FGFR-driven cancers .
    SHP244
  • HY-133021
    Arazine

    N-Acetyl-S-farnesyl-L-cysteine

    		 DNA Methyltransferase Inflammation/Immunology
    Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site .
    Arazine
  • HY-125969
    Rtt109 inhibitor 1

    		Histone Acetyltransferase Fungal Infection
    Rtt109 inhibitor 1 (Compound 1) is an inhibitor for histone acetyltransferase Rtt109 through a tight binding, uncompetitive system. Rtt109 inhibitor 1 exhibits antifungal activity through acetylation at H3K56 site .
    Rtt109 inhibitor 1
  • HY-128379
    Labetalone hydrochloride

    		Drug Metabolite Others
    Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites .
    Labetalone hydrochloride
  • HY-P11421
    Cys-His Tag

    		Biochemical Assay Reagents Others
    Cys-His Tag is a dual-purpose protein tag combining a cysteine residue and a Histidine tag. Cys-His Tag can be used to improve marker specificity or introduce covalent binding sites .
    Cys-His Tag
  • HY-177373
    P21 saRNA

    		CDK Cancer
    P21 saRNA is a small activating RNA (saRNA) targeting the p21 genes. P21 saRNA induce expression of the p21 genes, and targets the p21 promoters at ?322 relative to gene's transcription start site .
    P21 saRNA
  • HY-126932
    TTC-352

    		Estrogen Receptor/ERR Cancer
    TTC-352 is an orally bioavailable selective human estrogen receptor (ER) α partial agonist (ShERPA). TTC-352 inhibits the growth of three ER+ breast cancer cells. TTC-352 induces tumor regression accompanied by exit of ERα from the nucleus to extranuclear sites .
    TTC-352
  • HY-100143
    Pentiapine

    CGS 10746

    		 Dopamine Receptor Neurological Disease
    Pentiapine (CGS 10746) is a dopamine release inhibitor without binding to synaptic dopamine receptor sites .
    Pentiapine
  • HY-118168
    A 9387

    Galosfen

    		 Topoisomerase Others
    A9387 is an inhibitor of the Tn3 Resolvase, which promotes site-specific recombination reactions between two directly repeated recombination sites. Several inhibitors have been isolated that inhibit this event. A9387 inhibits the binding of resolvase to the res site .
    A 9387
  • HY-123602
    CGP 55802A

    		iGluR Neurological Disease
    CGP 55802A is a novel photoaffinity ligand for in situ labeling of NMDA receptors with high selectivity for the glutamate recognition site .
    CGP 55802A
  • HY-16372
    CP 461

    OSI-461

    		 Apoptosis Microtubule/Tubulin Cancer
    CP-461 (OSI-461) is a selective apoptotic antineoplastic drug (SAAND) by engaging tubulin on colchicine site
    CP 461
  • HY-N15270
    S-Secoantioquine

    Secantioquine

    		 Dopamine Receptor Others
    S-Secoantioquine (Secantioquine) is a bisbenzylisoquinoline alkaloid secoderivative. In the rat striate membrane experiment, S-Secoantioquine shows weak displacement activity on 3H-SCH 23390 binding site, and certain displacement activity on 3H-raclopride binding site .
    S-Secoantioquine
  • HY-165026
    1,2,3-tri-γ-Linolenoyl glycerol

    γ-Linolenic acid triglyceride; γ-Linolenin

    		 Endogenous Metabolite Others
    1,2,3-tri-γ-Linolenoyl glycerol is a triacylglycerol with γ-linolenic acid attached to the three esterification sites (1, 2 and 3) of glycerol .
    1,2,3-tri-γ-Linolenoyl glycerol
  • HY-N11896A
    10-Hydroxyaloin A

    		SARS-CoV Infection Inflammation/Immunology
    10-10-Hydroxyaloin A is potent SARS-CoV-2 inhibitor. 10-Hydroxyaloin A exhibits significant efficacy to bind SARS-Cov-2 Mpro active site .
    10-Hydroxyaloin A
  • HY-119105
    LY81067

    		GABA Receptor Neurological Disease
    LY81067, a diaryltriazine, effectively protects against Pentylenetetrazole- and Picrotoxin-induced convulsions in mice. LY81067 exerts its anticonvulsant effects by binding to or near Picrotoxin (HY-101391) binding sites .
    LY81067
  • HY-177374
    Ecad saRNA

    		Cadherin Cancer
    Ecad saRNA is a small activating RNA (saRNA) targeting the E-cadherin genes. Ecad saRNA induce expression of the E-cadherin genes, and targets the E-cadherin promoters at ?215 relative to gene's transcription start site .
    Ecad saRNA
  • HY-B1657
    Fosphenytoin

    		Drug Intermediate Neurological Disease
    Fosphenytoin is a phosphate ester proagent developed as an alternative to intravenous phenytoin for acute intervention of seizures. Fosphenytoin has advantages including more convenient and rapid intravenous administration, availability for intramuscular injection, and low potential for adverse local reactions at injection sites .
    Fosphenytoin
  • HY-128379R
    Labetalone hydrochloride (Standard)

    		Drug Metabolite Reference Standards Others
    Labetalone (hydrochloride) (Standard) is the analytical standard of Labetalone (hydrochloride). This product is intended for research and analytical applications. Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites .
    Labetalone hydrochloride (Standard)
  • HY-115749A
    (Rac)-Luciferin 6′-methyl ether sodium

    (Rac)-6′-Methoxyluciferin sodium

    		 Drug Derivative Others
    D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) sodium is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 μM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site .
    (Rac)-Luciferin 6′-methyl ether sodium
  • HY-W063263
    1-Acetylpyrrolidine

    N-Acetylpyrrolidine

    		 Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Cancer
    1-Acetylpyrrolidine (N-acetylpyrrolidine) is a smoking-related metabolite. 1-Acetylpyrrolidine can induce low methylation at DNA CpG site. 1-Acetylpyrrolidine can be used for the research on the mechanisms of smoking-related diseases and the development of biomarkers .
    1-Acetylpyrrolidine
  • HY-P3234
    Ac-ESMD-CHO

    		Casein Kinase Others
    Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .
    Ac-ESMD-CHO
  • HY-P10101
    APT STAT3, scrambled

    APTscr

    		 STAT Others
    APT STAT3, scrambled (APTscr), a control peptide of STAT3-specific aptide (APTSTAT3), does not bind STAT3. APT STAT3, scrambled contains the same trpzip scaffold but with a scrambled sequence in the target-binding site .
    APT STAT3, scrambled
  • HY-P3606
    GnRH Associated Peptide (1-24), human

    GAP (1-24), human

    		 GnRH Receptor Endocrinology
    GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .
    GnRH Associated Peptide (1-24), human

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