2′-Thioadenosine
2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site.
For research use only. We do not sell to patients.
- CAS No.: 136904-69-3
- Formula: C10H13N5O3S
- Molecular Weight:283.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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ErbB1 |
ErbB2 45 μM (IC50) |
2'-Thioadenosine (50 µM) exhibits no activity against FGF, PDGF orinsulin receptor tyrosine kinases[1].
2'-Thioadenosine covalently inactivates ErbB-1, which is reversed by 1 mM Dithiothreitol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 136904-69-3
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Molecular Weight 283.31
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Formula C10H13N5O3S
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SMILES
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3S)C2=NC=N1
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Synonyms
PD157432
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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